The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process.
The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process.
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DOI：
10.1146/annurev-biophys-070816-034034
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发表时间：
2018-05-20
影响因子：
12.4
通讯作者：
Frank J
中科院分区：
文献类型：
--
作者：
Hashem Y;Frank J
真核生物翻译起始是一个高度调控的限速过程。它导致涉及十几种真核起始因子（eIF）的许多瞬时和中间复合物的组装和分解。该过程在起始密码子的容纳中达到高潮，该起始密码子标志着在适当的核糖体位点处的开放阅读框的开始。尽管近半个世纪来，数百个研究小组对这一过程进行了广泛的研究，但直到最近，特别是在过去的十年中，我们才对真核生物翻译起始过程的机制有了更深入的了解。这种知识的进步部分是由于结构生物学的贡献，它揭示了各种真核生物起始因子的不同功能的分子力学。在这篇综述中，我们专注于结构生物学对真核生物起始过程的理解的贡献，这是一个长期存在的拼图游戏，刚刚开始产生更大的画面。
Translation initiation in eukaryotes is a highly regulated and rate-limiting process. It results in the assembly and disassembly of numerous transient and intermediate complexes involving over a dozen eukaryotic initiation factors (eIFs). This process culminates in the accommodation of a start codon marking the beginning of an open reading frame at the appropriate ribosomal site. Although this process has been extensively studied by hundreds of groups for nearly half a century, it has been only recently, especially during the last decade, that we have gained deeper insight into the mechanics of the eukaryotic translation initiation process. This advance in knowledge is due in part to the contributions of structural biology, which have shed light on the molecular mechanics underlying the different functions of various eukaryotic initiation factors. In this review, we focus exclusively on the contribution of structural biology to the understanding of the eukaryotic initiation process, a long-standing jigsaw puzzle that is just starting to yield the bigger picture.
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