Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer.
Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer.
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DOI：
10.1007/s10549-018-4911-y
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发表时间：
2018-11
影响因子：
3.8
通讯作者：
Hurria A
中科院分区：
文献类型：
--
作者：
Chen BT;Jin T;Patel SK;Ye N;Sun CL;Ma H;Rockne RC;Root JC;Saykin AJ;Ahles TA;Holodny AI;Prakash N;Mortimer J;Waisman J;Yuan Y;Li D;Somlo G;Vazquez J;Levi A;Tan H;Yang R;Katheria V;Hurria A
本研究的目的是评估老年乳腺癌患者辅助化疗前后脑灰质密度(GMD)的纵向变化。我们招募了16名年龄60岁、接受辅助化疗(CT)的I-III期乳腺癌患者和15名年龄和性别匹配的健康对照组(HC)。CT组在辅助化疗前(时间点1，TP1)和化疗后1个月内(时间点2，TP2)分别行脑MRI和NIH认知测试工具箱检查。HC组在匹配的时间间隔内接受相同的评估。用基于体素的形态计量学方法评价牙周膜密度。CT组平均年龄67岁，HC组平均年龄68.5岁。从TP1到TP2，化疗组GMD显著降低。与HC组相比，CT组涉及左侧扣带回前部、右侧岛叶和左侧颞中回的脑区从Tp1到Tp2的GMD值降低有统计学意义(经家族误差校正的 <； )。HC组左侧岛叶GMD值与基线列表分类工作记忆评分呈正相关( <； ，P<0.05)。从tp1到tp2的认知测试分数的变化与GMD的变化没有相关性(pFWE校正的 <； 0.05)。我们的发现表明，在老年乳腺癌患者中，GMD的减少与辅助化疗有关。需要进一步的研究来了解神经影像表现的临床意义。这项研究注册在ClinicalTrials.gov(NCT01992432)上。
The purpose of this study was to evaluate longitudinal changes in brain gray matter density (GMD) before and after adjuvant chemotherapy in older women with breast cancer. We recruited 16 women aged ≥ 60 years with stage I–III breast cancers receiving adjuvant chemotherapy (CT) and 15 age- and sex-matched healthy controls (HC). The CT group underwent brain MRI and the NIH Toolbox for Cognition testing prior to adjuvant chemotherapy (time point 1, TP1) and within 1 month after chemotherapy (time point 2, TP2). The HC group underwent the same assessments at matched intervals. GMD was evaluated with the voxel-based morphometry. The mean age was 67 years in the CT group and 68.5 years in the HC group. There was significant GMD reduction within the chemotherapy group from TP1 to TP2. Compared to the HC group, the CT group displayed statistically significantly greater GMD reductions from TP1 to TP2 in the brain regions involving the left anterior cingulate gyrus, right insula, and left middle temporal gyrus (pFWE(family-wise error)-corrected < 0.05). The baseline GMD in left insula was positively correlated with the baseline list-sorting working memory score in the HC group (pFWE-corrected < 0.05). No correlation was observed for the changes in GMD with the changes in cognitive testing scores from TP1 to TP2 (pFWE-corrected < 0.05). Our findings indicate that GMD reductions were associated with adjuvant chemotherapy in older women with breast cancer. Future studies are needed to understand the clinical significance of the neuroimaging findings. This study is registered on ClinicalTrials.gov (NCT01992432).
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DOI：
10.3390/s130303169
发表时间：
2013-03-06
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Scherling CS;Smith A
通讯作者：
Smith A
影响因子：
3.2
作者：
McDonald, Brenna C.;Saykin, Andrew J.
通讯作者：
Saykin, Andrew J.
DOI：
10.1080/13803390903032537
发表时间：
2010-01-01
影响因子：
2.2
作者：
Cimprich, Bernadine;Reuter-Lorenz, Patricia;Welsh, Robert C.
通讯作者：
Welsh, Robert C.
影响因子：
9.9
作者：
Weintraub, Sandra;Dikmen, Sureyya S.;Gershon, Richard C.
通讯作者：
Gershon, Richard C.
影响因子：
5.8
作者：
Hayat, Matthew J.;Howlader, Nadia;Edwards, Brenda K.
通讯作者：
Edwards, Brenda K.