Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle.
Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle.
复制标题
人体骨骼肌中葡萄糖和胰岛素对糖原合成酶和磷酸化酶活性的调节。
DOI：
10.1172/jci113069
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Clifton Bogardus
中科院分区：
文献类型：
--
作者：
Hannele Yki;David M. Mott;Andrew A. Young;K. Stone;Clifton Bogardus
我们检测了人肌肉糖原合成酶和磷酸化酶激活的胰岛素剂量-反应特性。我们还确定了在固定的胰岛素浓度下增加高血糖处理葡萄糖的速度是否会激活糖原合成酶。血浆胰岛素而不是葡萄糖的生理性递增增加了糖原合成酶的部分活性。胰岛素刺激全身ED50：S与前臂葡萄糖处理ED50相似，不受血糖影响。在每种葡萄糖浓度下，糖原合成酶的激活与胰岛素介导的全身和前臂葡萄糖处置呈指数相关。胰岛素和葡萄糖均不影响糖原磷酸化酶活性。这些结果表明，胰岛素而不是葡萄糖本身的处置速度通过一种涉及糖原合成酶而不是磷酸化酶去磷酸化的机制来调节糖原合成。这意味着在胰岛素抵抗状态中发现的低糖原合成酶活性是胰岛素作用受损的结果，而不是葡萄糖处置减少的结果。
We examined the insulin dose-response characteristics of human muscle glycogen synthase and phosphorylase activation. We also determined whether increasing the rate of glucose disposal by hyperglycemia at a fixed insulin concentration activates glycogen synthase. Physiological increments in plasma insulin but not glucose increased the fractional activity of glycogen synthase. The ED50: s for insulin stimulation of whole body and forearm glucose disposal were similar and unaffected by glycemia. Glycogen synthase activation was exponentially related to the insulin-mediated component of whole body and forearm glucose disposal at each glucose concentration. Neither insulin nor glucose changed glycogen phosphorylase activity. These results suggest that insulin but not the rate of glucose disposal per se regulates glycogen synthesis by a mechanism that involves dephosphorylation of glycogen synthase but not phosphorylase. This implies that the low glycogen synthase activities found in insulin-resistant states are a consequence of impaired insulin action rather than reduced glucose disposal.
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影响因子：
15.9
作者：
FERRANNINI, E;SMITH, JD;DEFRONZO, RA
通讯作者：
DEFRONZO, RA
影响因子：
9.8
作者：
ABUMRAD, NN;RABIN, D;LACY, WW
通讯作者：
LACY, WW
影响因子：
20.3
作者：
BERGMAN, RN;FINEGOOD, DT;ADER, M
通讯作者：
ADER, M
胰岛素介质及其通过蛋白质磷酸化对代谢的控制。
DOI：
10.1016/b978-0-12-571138-8.50017-2
发表时间：
1982
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Larner,J;Cheng,K;Schwartz,C;Kikuchi,K;Tamura,S;Creacy,S;Dubler,R;Galasko,G;Pullin,C;Katz,M
通讯作者：
Katz,M