Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma.
Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma.
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DOI：
10.1016/j.coph.2018.04.003
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发表时间：
2018-08
影响因子：
4
通讯作者：
Whelan KA
中科院分区：
文献类型：
--
作者：
Hall TM;Tétreault MP;Hamilton KE;Whelan KA
食道鳞状细胞癌(ESCC)是最具侵袭性的人类恶性肿瘤之一，在世界范围内造成巨大的健康负担。自噬是一种进化上保守的分解代谢过程，它降解和回收受损的细胞器和错误折叠的蛋白质来维持细胞内环境的稳定。自噬的改变与包括ESCC在内的癌症发病机制有关；然而，自噬在ESCC中的功能作用仍不清楚。在这里，我们讨论自噬效应在ESCC中的临床相关性，并回顾当前关于自噬促进ESCC的分子机制的知识。我们强调了自噬在ESCC中的细胞保护作用，并讨论了自噬抑制剂作为新的实验疗法来增强抗癌治疗的效果和/或克服ESCC中的治疗耐药性。
Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.
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影响因子：
2.9
作者：
Han X;Wang Z;Hu B;Xu J
通讯作者：
Xu J
二甲双胍通过下调 Stat3 信号促进食管鳞状细胞癌自噬和凋亡
影响因子：
9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cancer Genome Atlas Research Network;Analysis Working Group: Asan University;BC Cancer Agency;Brigham and Women’s Hospital;Broad Institute;Brown University;Case Western Reserve University;Dana-Farber Cancer Institute;Duke University;Greater Poland Cancer Centre;Harvard Medical School;Institute for Systems Biology;KU Leuven;Mayo Clinic;Memorial Sloan Kettering Cancer Center;National Cancer Institute;Nationwide Children’s Hospital;Stanford University;University of Alabama;University of Michigan;University of North Carolina;University of Pittsburgh;University of Rochester;University of Southern California;University of Texas MD Anderson Cancer Center;University of Washington;Van Andel Research Institute;Vanderbilt University;Washington University;Genome Sequencing Center: Broad Institute;Washington University in St. Louis;Genome Characterization Centers: BC Cancer Agency;Broad Institute;Harvard Medical School;Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University;University of North Carolina;University of Southern California Epigenome Center;University of Texas MD Anderson Cancer Center;Van Andel Research Institute;Genome Data Analysis Centers: Broad Institute;Brown University:;Harvard Medical School;Institute for Systems Biology;Memorial Sloan Kettering Cancer Center;University of California Santa Cruz;University of Texas MD Anderson Cancer Center;Biospecimen Core Resource: International Genomics Consortium;Research Institute at Nationwide Children’s Hospital;Tissue Source Sites: Analytic Biologic Services;Asan Medical Center;Asterand Bioscience;Barretos Cancer Hospital;BioreclamationIVT;Botkin Municipal Clinic;Chonnam National University Medical School;Christiana Care Health System;Cureline;Duke University;Emory University;Erasmus University;Indiana University School of Medicine;Institute of Oncology of Moldova;International Genomics Consortium;Invidumed;Israelitisches Krankenhaus Hamburg;Keimyung University School of Medicine;Memorial Sloan Kettering Cancer Center;National Cancer Center Goyang;Ontario Tumour Bank;Peter MacCallum Cancer Centre;Pusan National University Medical School;Ribeirão Preto Medical School;St. Joseph’s Hospital &Medical Center;St. Petersburg Academic University;Tayside Tissue Bank;University of Dundee;University of Kansas Medical Center;University of Michigan;University of North Carolina at Chapel Hill;University of Pittsburgh School of Medicine;University of Texas MD Anderson Cancer Center;Disease Working Group: Duke University;Memorial Sloan Kettering Cancer Center;National Cancer Institute;University of Texas MD Anderson Cancer Center;Yonsei University College of Medicine;Data Coordination Center: CSRA Inc.;Project Team: National Institutes of Health
通讯作者：
Project Team: National Institutes of Health
影响因子：
28.2
作者：
Karsli-Uzunbas G;Guo JY;Price S;Teng X;Laddha SV;Khor S;Kalaany NY;Jacks T;Chan CS;Rabinowitz JD;White E
通讯作者：
White E
影响因子：
13.3
作者：
Mahalingam, Devalingam;Mita, Monica;Carew, Jennifer S.
通讯作者：
Carew, Jennifer S.