Advances in the development of biodegradable coronary stents: A translational perspective.
Advances in the development of biodegradable coronary stents: A translational perspective.
复制标题
生物可降解冠状动脉支架的研究进展：平移视角。
DOI：
10.1016/j.mtbio.2022.100368
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发表时间：
2022-12
影响因子：
8.2
通讯作者：
Hu, Bo
中科院分区：
文献类型：
--
作者：
Zong, Jiabin;He, Quanwei;Liu, Yuxiao;Qiu, Min;Wu, Jiehong;Hu, Bo
关键词：
心血管支架植入术是治疗冠状动脉疾病的重要手段。裸金属支架和药物洗脱支架显示出良好的临床效果，然而，它们的永久存在可能会产生并发症。近年来，许多临床前和临床试验已经评估了生物可吸收支架的性能，包括聚合物支架和镁基支架。三维（3D）打印形状记忆聚合物材料能够实现支架的自我部署，并为个体化治疗提供了一种新的方法。新型生物可吸收金属支架如铁基和锌基支架也在研究和改进中。然而，伴随临床转化的新型生物可吸收支架的开发仍然耗时且具有挑战性。本文综述了基于临床前/临床试验的生物可吸收支架的发展，重点介绍了支架的转化研究和新技术（如生物可吸收电子支架与生物传感器集成）。这些发现有望启发新型支架的设计和优化方法，以提高心血管疾病治疗的疗效。生物可吸收支架可以克服不可降解支架的局限性。3D打印形状记忆聚合物支架可以带来更好的临床效果。从平移角度看镁、铁和锌基支架的进展。集成了生物传感器的电子支架可以实时传递支架的状态。体内支架性能评估的进展。
Implantation of cardiovascular stents is an important therapeutic method to treat coronary artery diseases. Bare-metal and drug-eluting stents show promising clinical outcomes, however, their permanent presence may create complications. In recent years, numerous preclinical and clinical trials have evaluated the properties of bioresorbable stents, including polymer and magnesium-based stents. Three-dimensional (3D) printed-shape-memory polymeric materials enable the self-deployment of stents and provide a novel approach for individualized treatment. Novel bioresorbable metallic stents such as iron- and zinc-based stents have also been investigated and refined. However, the development of novel bioresorbable stents accompanied by clinical translation remains time-consuming and challenging. This review comprehensively summarizes the development of bioresorbable stents based on their preclinical/clinical trials and highlights translational research as well as novel technologies for stents (e.g., bioresorbable electronic stents integrated with biosensors). These findings are expected to inspire the design of novel stents and optimization approaches to improve the efficacy of treatments for cardiovascular diseases. Bioresorbable stents can overcome the limitations of non-degradable stents. 3D printing of shape-memory polymeric stents can lead to better clinical outcomes. Advances in Mg-, Fe- and Zn-based stents from a translational perspective. Electronic stents integrated with biosensors can covey stent status in real time. Development in the assessment of stent performance in vivo.
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影响因子：
2.9
作者：
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通讯作者：
Bosiers, Marc
DOI：
10.1016/j.msec.2020.111172
发表时间：
2020-11-01
影响因子：
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