Adaptive servoventilation improves cardiac function and respiratory stability.
Adaptive servoventilation improves cardiac function and respiratory stability.
复制标题
DOI：
10.1007/s00392-010-0216-9
复制
发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Horstkotte D
中科院分区：
文献类型：
--
作者：
Oldenburg O;Bitter T;Lehmann R;Korte S;Dimitriadis Z;Faber L;Schmidt A;Westerheide N;Horstkotte D
慢性心力衰竭（CHF）患者的Cheyne-Stokes呼吸（CSR）是主要的预后影响因素，表达呼吸不稳定。其他参数包括白天pCO2、运动时VE/ vco2斜率、运动振荡通气（EOV）和中枢CO2受体敏感性增加。引入自适应伺服通气（ASV）专门治疗慢性心力衰竭患者的CSR。本研究的目的是探讨ASV对CSR、心功能和呼吸稳定性的影响。共有105例CHF患者（NYHA≥II，左室射血分数(EF)≤40%）和CSR（呼吸暂停-低通气指数≥15/h）符合纳入标准。根据ASV治疗依从性（随访6.7±3.2个月）将该组分为对照组（拒绝ASV治疗或使用ASV <50%可能夜数和/或<4小时/夜；n = 59）和ASV治疗依从组（n = 56）。在ASV组中，呼吸机治疗能够有效治疗CSR。与对照组相比，NYHA分级、EF、摄氧量、6分钟步行距离和NT-proBNP显著改善。此外，仅在这些患者中，运动时的pCO2、VE/ vco2斜率、EOV和中枢CO2受体敏感性均有所改善。在合并CSR的CHF患者中，ASV可能能够改善SDB、心功能和呼吸稳定性等参数。
Cheyne–Stokes respiration (CSR) in patients with chronic heart failure (CHF) is of major prognostic impact and expresses respiratory instability. Other parameters are daytime pCO2, VE/VCO2-slope during exercise, exertional oscillatory ventilation (EOV), and increased sensitivity of central CO2 receptors. Adaptive servoventilation (ASV) was introduced to specifically treat CSR in CHF. Aim of this study was to investigate ASV effects on CSR, cardiac function, and respiratory stability. A total of 105 patients with CHF (NYHA ≥ II, left ventricular ejection fraction (EF) ≤ 40%) and CSR (apnoea–hypopnoea index ≥ 15/h) met inclusion criteria. According to adherence to ASV treatment (follow-up of 6.7 ± 3.2 months) this group was divided into controls (rejection of ASV treatment or usage <50% of nights possible and/or <4 h/night; n = 59) and ASV (n = 56) adhered patients. In the ASV group, ventilator therapy was able to effectively treat CSR. In contrast to controls, NYHA class, EF, oxygen uptake, 6-min walking distance, and NT-proBNP improved significantly. Moreover, exclusively in these patients pCO2, VE/VCO2-slope during exercise, EOV, and central CO2 receptor sensitivity improved. In CHF patients with CSR, ASV might be able to improve parameters of SDB, cardiac function, and respiratory stability.
登录
查看更多内容
影响因子：
9.6
作者：
Allam, Joanne Shirine;Olson, Eric J.;Morgenthaler, Timothy I.
通讯作者：
Morgenthaler, Timothy I.
影响因子：
5.7
作者：
Philippe, C;Stoïca-Herman, M;d'Ortho, MP
通讯作者：
d'Ortho, MP
影响因子：
4.8
作者：
Pires, LA;Abraham, WT;Johnson, KM
通讯作者：
Johnson, KM
DOI：
10.1164/ajrccm.152.2.7633695
发表时间：
1995-08-01
影响因子：
24.7
作者：
NAUGHTON, MT;BENARD, DC;BRADLEY, TD
通讯作者：
BRADLEY, TD
影响因子：
24.3
作者：
Pinna, G. D.;Maestri, R.;Sleight, P.
通讯作者：
Sleight, P.