Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection.
Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection.
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DOI：
10.1155/2020/2045341
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发表时间：
2020
影响因子：
2.2
通讯作者：
Dai Y
中科院分区：
文献类型：
--
作者：
Dai W;Chen X;Xu X;Leng Z;Yu W;Lin H;Li H;Lin J;Qiu Z;Dai Y
由新型冠状病毒SARS-CoV-2引起的2019冠状病毒病（COVID-19）于2019年12月首次在中国武汉被发现，此后已在全球传播，导致持续的大流行。然而，对无症状患者的研究仍然很少，对其潜在传播风险的认识仍然不足。本研究在浙江省开展流行病学调查，了解新型冠状病毒肺炎无症状患者的流行病学及临床特征。本研究对2020年1月21日至3月16日在浙江多地医院住院的22例无症状感染者和234例有症状感染者进行回顾性研究。比较分析轻症患者的流行病学、人口学特征、临床表现及实验室资料。无症状患者的中位年龄为28岁，有症状患者的中位年龄为48岁。无症状患者中女性占77.3%，有症状患者中女性占36.3% （p < 0.001）。无症状患者合并合并疾病的比例为4.5%，有症状患者合并合并疾病的比例为38.0% （p=0.002）。无症状组CRP升高的比例为13.6%，有症状组为61.1% （p < 0.001）。无症状组接受抗病毒治疗的比例为45.5%，有症状组为97.9% （p < 0.001）。无症状组接受氧疗的患者比例为22.7%，有症状组为99.1% （p < 0.001）。截至2020年3月16日，所有患者均出院，无症状患者住院期间均未出现症状。无症状患者感染至出院的中位病程为21.5天，有症状患者为22天。无症状患者也具有传染性；仅仅依靠临床症状、血细胞检查和放射检查，会导致大多数患者误诊，导致病毒传播。调查病史是筛查无症状患者的最佳策略，尤其是年轻人、女性和无并存疾病的人群，这些人群感染后更容易出现无症状。虽然预后良好，但对无症状患者进行隔离至关重要，在核酸检测呈阴性之前不要过早结束隔离。
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2, was first identified in December 2019 in Wuhan, China, and has since spread globally, resulting in an ongoing pandemic. However, the study of asymptomatic patients is still rare, and the understanding of its potential transmission risk is still insufficient. In this study, epidemiological investigations were conducted in the Zhejiang province to understand the epidemiology and clinical characteristics of asymptomatic patients with COVID-19. This retrospective study was carried out on 22 asymptomatic patients and 234 symptomatic patients with COVID-19 who were hospitalized in Zhejiang Duodi Hospital from January 21 to March 16, 2020. The characteristics of epidemiology, demography, clinical manifestations, and laboratory data of mild patients were compared and analyzed. The median age was 28 years in asymptomatic patients and 48 years in symptomatic patients. The proportion who were female was 77.3% in asymptomatic patients and 36.3% in symptomatic patients (p < 0.001). The proportion of patients with coexisting diseases was 4.5% in asymptomatic patients and 38.0% in symptomatic patients (p=0.002). The proportion of patients with increased CRP was 13.6% in the asymptomatic group and 61.1% in the symptomatic group (p < 0.001). The proportion of patients received antiviral therapy was 45.5% in the asymptomatic group and 97.9% in the symptomatic group (p < 0.001). The proportion of patients received oxygen therapy was 22.7% in the asymptomatic group and 99.1% in symptomatic patients (p < 0.001). By March 16, 2020, all patients were discharged from the hospital, and no symptoms had appeared in the asymptomatic patients during hospitalization. The median course of infection to discharge was 21.5 days in asymptomatic patients and 22 days in symptomatic patients. Asymptomatic patients are also infectious; relying only on clinical symptoms, blood cell tests, and radiology examination will lead to misdiagnosis of most patients, leading to the spread of the virus. Investigation of medical history is the best strategy for screening asymptomatic patients, especially young people, women, and people without coexisting disease, who are more likely to be asymptomatic when infected. Although the prognosis is good, isolation is critical for asymptomatic patients, and it is important not to end isolation early before a nucleic acid test turns negative.
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影响因子：
168.9
作者：
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120.7
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