Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation.
Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation.
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无同种异体移植血管病变的加速慢性皮肤变化：面部移植后 10 年结果报告。
DOI：
10.1016/j.surg.2020.01.010
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发表时间：
2020
期刊：
影响因子：
3.8
通讯作者：
Riella,Leonard
中科院分区：
文献类型：
--
作者：
Kollar,Branislav;Rizzo,NatalieM;Borges,ThiagoJ;Haug,Valentin;Abdulrazzak,Obada;Kauke,Martin;Safi,Ali-Farid;Lian,ChristineG;Marty,FranciscoM;Rutherford,AnnaE;Mitchell,RichardN;Murphy,GeorgeF;Tullius,StefanG;Riella,Leonard
背景科学文献中很少报道面部移植后的长期结果。在这里，我们提出的结果数据的一部分面部同种异体移植受体10年后transplant.MethodsMedical记录进行了审查的功能和心理社会的结果以及并发症。尸检组织的病理学分析和皮肤免疫细胞的表征performed.ResultsThe患者保留了长期的运动和感觉功能，虽然与一个显着的下降后5年的感觉功能。病人重新融入社会的特点是与家人重新联系并参加公共社会活动。免疫抑制治疗包括他克莫司（第一年后的目标水平为6-8 ng/mL）、霉酚酸酯和泼尼松，而类固醇在第1年至第7年之间完全停用。平均每年发生一次II级或更高级别的急性细胞排斥反应，并导致慢性皮肤变化（乳头状真皮硬化伴浅表玻璃样变、表皮变薄伴网嵴缺失、外分泌周纤维化），但移植血管、肌肉、脂肪组织和骨均未受影响。与天然皮肤相比，同种异体皮肤的特征在于产生CD 4 + TNF-α/IL 17 A的T细胞的数量增加。长期肾功能维持在60 mL/min估计肾小球滤过率。不幸的是，预先存在的丙型肝炎病毒感染肝硬化是耐3治疗与新的直接作用的抗病毒药物，并最终肝细胞癌的发展，造成病人的死亡10年后transplantation.ConclusionThis报告表明，面对移植可以保持其功能至少10年。慢性皮肤变化可独立于同种异体移植物血管病变发生。
BackgroundLong-term outcomes after face transplantation are rarely reported in the scientific literature. Here we present outcome data of a partial face allograft recipient 10 years after transplantation.MethodsMedical records were reviewed for functional and psychosocial outcomes as well as complications. Histopathologic analyses of autopsy tissues and characterization of skin immune cells were performed.ResultsThe patient retained long-term motor and sensory function, though with a noticeable drop in sensory function after year 5. Social reintegration of the patient was marked by reconnection with his family and participation in public social activities. Immunosuppressive therapy consisted of tacrolimus (target levels 6–8 ng/mL after the first year), mycophenolate, and prednisone, while steroids were completely weaned between years 1 and 7. One acute cellular rejection episode of grade II or higher occurred on average per year and led to chronic skin changes (papillary dermal sclerosis with superficial hyalinization, epidermal thinning with loss of rete ridges, perieccrine fibrosis), but the allograft vessels, muscles, adipose tissue, and bone were spared. Allograft skin was characterized by increased number of CD4+ TNF-α/IL17A producing T-cells as compared with native skin. Long-term kidney function was maintained at 60 mL/min estimated glomerular filtration rate. Unfortunately, the preexisting hepatitis C virus infection with liver cirrhosis was resistant to 3 treatments with new direct-acting antivirals and eventually hepatocellular carcinoma developed, causing the patient’s death 10 years after transplantation.ConclusionThis report suggests that face transplants can maintain their function for at least 10 years. Chronic skin changes can occur independently of allograft vasculopathy.
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影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
影响因子：
6.5
作者：
Chiricozzi, Andrea;Guttman-Yassky, Emma;Krueger, James G.
通讯作者：
Krueger, James G.
DOI：
10.1016/j.ijom.2019.05.003
发表时间：
2020-02-01
影响因子：
2.4
作者：
Bettoni, J.;Baledent, O.;Dakpe, S.
通讯作者：
Dakpe, S.
影响因子：
158.5
作者：
Bourliere, M.;Gordon, S. C.;Zeuzem, S.
通讯作者：
Zeuzem, S.
血管化复合同种异体移植：仔细观察班夫工作分类
影响因子：
3.1
作者：
Michelle Schneider;A. Cardones;M. Selim;L. Cendales
通讯作者：
L. Cendales