Nanodevices in diagnostics.
Nanodevices in diagnostics.
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DOI：
10.1002/wnan.82
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发表时间：
2011-01
影响因子：
8.6
通讯作者：
Ferrari, Mauro
中科院分区：
文献类型：
--
作者：
Hu, Ye;Fine, Daniel H.;Tasciotti, Ennio;Bouamrani, Ali;Ferrari, Mauro
疾病的实时、个性化和高灵敏度早期诊断仍然是现代医学面临的一项重大挑战。由于能够在纳米尺度上与物质相互作用，纳米技术架构和材料的发展有可能使亚细胞和分子检测突破传统诊断模式的局限。至少，纳米技术应该能够极大地加速生物标志物的发现，并促进疾病监测，尤其是对具有高度分子和成分异质性的疾病的监测。本文概述了几种最有前景的纳米器件和纳米材料及其在临床实践中的应用。使纳米材料和器件适应临床应用的大量工作（涉及大规模跨学科合作）已经在进行中，纳米技术有可能成为一种重要的使能诊断技术。
The real-time, personalized and highly sensitive early-stage diagnosis of disease remains an important challenge in modern medicine. With the ability to interact with matter at the nanoscale, the development of nanotechnology architectures and materials could potentially extend subcellular and molecular detection beyond the limits of conventional diagnostic modalities. At the very least, nanotechnology should be able to dramatically accelerate biomarker discovery, as well as facilitate disease monitoring, especially of maladies presenting a high degree of molecular and compositional heterogeneity. This article gives an overview of several of the most promising nanodevices and nanomaterials along with their applications in clinical practice. Significant work to adapt nanoscale materials and devices to clinical applications involving large interdisciplinary collaborations is already underway with the potential for nanotechnology to become an important enabling diagnostic technology.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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