Opportunities and challenges to engineer 3D models of tumor-adaptive immune interactions.
Opportunities and challenges to engineer 3D models of tumor-adaptive immune interactions.
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DOI：
10.3389/fimmu.2023.1162905
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
增强适应性免疫是开发下一代癌症疗法的关键目标。浸润肿瘤的T和B细胞通过与局部微环境的复杂相互作用显著影响癌症进展。癌细胞通过劫持正常的免疫途径来逃避和限制这些免疫反应。目前使用传统原代细胞、细胞系或动物的实验模型在研究与人类生物学和临床转化直接相关的癌症-免疫相互作用方面存在局限性。因此，在局部和全身水平上模拟这种相互作用的工程方法对于加快开发更好的治疗和诊断工具至关重要。在这篇综述中，我们讨论了工程肿瘤免疫微环境（TME）的挑战，最新进展和未来的发展方向，包括适应性免疫的关键要素。我们首先概述了最近的研究，这些研究促进了我们对适应性免疫系统在肿瘤微环境中作用的理解。接下来，我们讨论了最近的发展，在三维体外模型和工程方法，已被用来研究癌症和基质细胞与B和T淋巴细胞的相互作用。我们总结了3D生物工程的最新进展，并讨论了3D肿瘤模型的需要，更好地结合适应性免疫和肿瘤微环境的复杂相互作用的元素。最后，我们提供了一个观点，对当前的挑战和未来的方向建模癌症免疫相互作用，旨在确定新的生物学目标的诊断和治疗。
Augmenting adaptive immunity is a critical goal for developing next-generation cancer therapies. T and B cells infiltrating the tumor dramatically influence cancer progression through complex interactions with the local microenvironment. Cancer cells evade and limit these immune responses by hijacking normal immunologic pathways. Current experimental models using conventional primary cells, cell lines, or animals have limitations for studying cancer-immune interactions directly relevant to human biology and clinical translation. Therefore, engineering methods to emulate such interplay at local and systemic levels are crucial to expedite the development of better therapies and diagnostic tools. In this review, we discuss the challenges, recent advances, and future directions toward engineering the tumor-immune microenvironment (TME), including key elements of adaptive immunity. We first offer an overview of the recent research that has advanced our understanding of the role of the adaptive immune system in the tumor microenvironment. Next, we discuss recent developments in 3D in-vitro models and engineering approaches that have been used to study the interaction of cancer and stromal cells with B and T lymphocytes. We summarize recent advancement in 3D bioengineering and discuss the need for 3D tumor models that better incorporate elements of the complex interplay of adaptive immunity and the tumor microenvironment. Finally, we provide a perspective on current challenges and future directions for modeling cancer-immune interactions aimed at identifying new biological targets for diagnostics and therapeutics.
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影响因子：
30.8
作者：
Danenberg E;Bardwell H;Zanotelli VRT;Provenzano E;Chin SF;Rueda OM;Green A;Rakha E;Aparicio S;Ellis IO;Bodenmiller B;Caldas C;Ali HR
通讯作者：
Ali HR
影响因子：
5.9
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Al-Hity G;Yang F;Campillo-Funollet E;Greenstein AE;Hunt H;Mampay M;Intabli H;Falcinelli M;Madzvamuse A;Venkataraman C;Flint MS
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Flint MS
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影响因子：
9
作者：
Dey, Madhuri;Kim, Myong Hwan;Nagamine, Momoka;Karhan, Ece;Kozhaya, Lina;Dogan, Mikail;Unutmaz, Derya;Ozbolat, Ibrahim T.
通讯作者：
Ozbolat, Ibrahim T.
影响因子：
5.8
作者：
Birmingham KG;O'Melia MJ;Bordy S;Reyes Aguilar D;El-Reyas B;Lesinski G;Thomas SN
通讯作者：
Thomas SN
影响因子：
64.8
作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
Jonsson, Goran