Curcumin nanoformulations: a future nanomedicine for cancer.

Curcumin nanoformulations: a future nanomedicine for cancer.
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姜黄素纳米制剂:一种未来的纳米药物癌。

DOI:
10.1016/j.drudis.2011.09.009
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发表时间:
2012-01
影响因子:
7.4
通讯作者:
Chauhan, Subhash C.
Chauhan, Subhash C.
中科院分区:
医学2区
文献类型:
--
作者:
Yallapu, Murali M.;Jaggi, Meena;Chauhan, Subhash C.

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姜黄素是一种从姜黄姜黄中提取的天然二酚化合物,已被证明是细胞内信号通路的调节剂,可控制癌细胞的生长、炎症、侵袭、凋亡和细胞死亡,揭示了其抗癌潜力。在这篇综述中,我们重点关注纳米粒子、自组装体、纳米凝胶、脂质体和复杂制造的设计和开发,以实现持续有效的姜黄素递送。我们还讨论了纳米姜黄素制剂的抗癌应用和临床益处。只有少数新颖的多功能和复合纳米系统策略提供同时治疗和成像特性。我们还总结了开发姜黄素递送平台和提高姜黄素生物利用度和抗癌治疗潜力的最新解决方案所面临的挑战。
Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion, apoptosis and cell death, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and up-to-date solutions for improving curcumin bioavailability and anticancer potential for therapy.
DOI: 10.1158/1940-6207.capr-10-0006
发表时间: 2011-08
期刊: Cancer prevention research (Philadelphia, Pa.)
影响因子: --
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