A Preclinical Evaluation of the Antitumor Activities of Edible and Medicinal Mushrooms: A Molecular Insight.
A Preclinical Evaluation of the Antitumor Activities of Edible and Medicinal Mushrooms: A Molecular Insight.
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DOI：
10.1177/1534735417736861
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发表时间：
2018-06
影响因子：
2.9
通讯作者：
Huang M
中科院分区：
文献类型：
--
作者：
Joseph TP;Chanda W;Padhiar AA;Batool S;LiQun S;Zhong M;Huang M
癌症是地球仪发病率和死亡率的主要原因。对于某些类型的癌症，化疗药物已被广泛用于治疗。然而，严重的副作用和耐药性的发展是这些药物的缺点。因此，开发无副作用或副作用最小的新药物至关重要。在这方面，天然化合物被公认为治疗包括癌症在内的多种人类疾病的药物。一类真菌，“蘑菇”，含有许多化合物，表现出有趣的生物活性，包括抗肿瘤活性。许多研究人员，包括我们自己的团队，正在关注不同蘑菇的抗癌潜力及其作用背后的潜在分子机制。本文综述了PI 3 K/AKT、Wnt-CTNNB 1和NF-κB信号通路及其基因变异的发生、这些变异与不同人类癌症的关系以及蘑菇源物质如何靶向这些通路的不同节点。我们已经提供了证据，提出了各种蘑菇源化合物的治疗属性和可能的分子作用模式。然而，抗癌作用通常在体外和体内模型中得到证实，在人群中进行的研究数量非常有限。我们相信，这篇综述将有助于研究界设计具体的临床前和临床研究，以测试蘑菇来源的化合物对不同癌症的抗癌潜力，这些癌症具有特定的遗传改变。
Cancer is the leading cause of morbidity and mortality around the globe. For certain types of cancer, chemotherapy drugs have been extensively used for treatment. However, severe side effects and the development of resistance are the drawbacks of these agents. Therefore, development of new agents with no or minimal side effects is of utmost importance. In this regard, natural compounds are well recognized as drugs in several human ailments, including cancer. One class of fungi, “mushrooms,” contains numerous compounds that exhibit interesting biological activities, including antitumor activity. Many researchers, including our own group, are focusing on the anticancer potential of different mushrooms and the underlying molecular mechanism behind their action. The aim of this review is to discuss PI3K/AKT, Wnt-CTNNB1, and NF-κB signaling pathways, the occurrence of genetic alterations in them, the association of these aberrations with different human cancers and how different nodes of these pathways are targeted by various substances of mushroom origin. We have given evidence to propose the therapeutic attributes and possible mode of molecular actions of various mushroom-originated compounds. However, anticancer effects were typically demonstrated in in vitro and in vivo models and very limited number of studies have been conducted in the human population. It is our belief that this review will help the research community in designing concrete preclinical and clinical studies to test the anticancer potential of mushroom-originated compounds on different cancers harboring particular genetic alteration(s).
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影响因子：
4.1
作者：
Dias DA;Urban S;Roessner U
通讯作者：
Roessner U
影响因子：
5.6
作者：
Erkel, G.;Wisser, G.;Anke, T.
通讯作者：
Anke, T.
影响因子：
--
作者：
Das, Arabinda;Miller, Rickey;Lee, Philip;Holden, Chrysanthe Alyssa;Lindhorst, Scott M.;Jaboin, Jerry;Vandergrift, William A., III;Banik, Naren L.;Giglio, Pierre;Varma, Abhay K.;Raizer, Jeffery J.;Patel, Sunil J.
通讯作者：
Patel, Sunil J.
影响因子：
64.8
作者：
Ding, Li;Getz, Gad;Wheeler, David A.;Mardis, Elaine R.;McLellan, Michael D.;Cibulskis, Kristian;Sougnez, Carrie;Greulich, Heidi;Muzny, Donna M.;Morgan, Margaret B.;Fulton, Lucinda;Fulton, Robert S.;Zhang, Qunyuan;Wendl, Michael C.;Lawrence, Michael S.;Larson, David E.;Chen, Ken;Dooling, David J.;Sabo, Aniko;Hawes, Alicia C.;Shen, Hua;Jhangiani, Shalini N.;Lewis, Lora R.;Hall, Otis;Zhu, Yiming;Mathew, Tittu;Ren, Yanru;Yao, Jiqiang;Scherer, Steven E.;Clerc, Kerstin;Metcalf, Ginger A.;Ng, Brian;Milosavljevic, Aleksandar;Gonzalez-Garay, Manuel L.;Osborne, John R.;Meyer, Rick;Shi, Xiaoqi;Tang, Yuzhu;Koboldt, Daniel C.;Lin, Ling;Abbott, Rachel;Miner, Tracie L.;Pohl, Craig;Fewell, Ginger;Haipek, Carrie;Schmidt, Heather;Dunford-Shore, Brian H.;Kraja, Aldi;Crosby, Seth D.;Sawyer, Christopher S.;Vickery, Tammi;Sander, Sacha;Robinson, Jody;Winckler, Wendy;Baldwin, Jennifer;Chirieac, Lucian R.;Dutt, Amit;Fennell, Tim;Hanna, Megan;Johnson, Bruce E.;Onofrio, Robert C.;Thomas, Roman K.;Tonon, Giovanni;Weir, Barbara A.;Zhao, Xiaojun;Ziaugra, Liuda;Zody, Michael C.;Giordano, Thomas;Orringer, Mark B.;Roth, Jack A.;Spitz, Margaret R.;Wistuba, Ignacio I.;Ozenberger, Bradley;Good, Peter J.;Chang, Andrew C.;Beer, David G.;Watson, Mark A.;Ladanyi, Marc;Broderick, Stephen;Yoshizawa, Akihiko;Travis, William D.;Pao, William;Province, Michael A.;Weinstock, George M.;Varmus, Harold E.;Gabriel, Stacey B.;Lander, Eric S.;Gibbs, Richard A.;Meyerson, Matthew;Wilson, Richard K.
通讯作者：
Wilson, Richard K.
影响因子：
64.5
作者：
Grivennikov SI;Greten FR;Karin M
通讯作者：
Karin M