Recent Advances in GPCR-Regulated Leukocyte Responses during Acute Cardiac Injury.
Recent Advances in GPCR-Regulated Leukocyte Responses during Acute Cardiac Injury.
复制标题
急性心脏损伤时GPCR调控白细胞反应的研究进展
DOI：
10.1016/j.cophys.2020.09.007
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发表时间：
2021-03
影响因子：
2.5
通讯作者：
Tilley DG
中科院分区：
文献类型：
--
作者：
Nayak TK;Tilley DG
急性心脏损伤如心肌梗死（MI）后，各种白细胞在组织损伤部位的受控激活和募集显著影响心脏结构和功能的慢性变化，最终影响宿主的生存。虽然最近的研究主要集中在白细胞如何对损伤做出反应，但如何有效地调节它们的反应以抑制不适应炎症并促进修复过程尚未完全了解。白细胞复杂的时空迁移和活化在很大程度上受各种趋化因子及其同源受体的控制，这些趋化因子属于G蛋白偶联受体（GPCR）家族。除了趋化因子受体外，白细胞还表达一系列额外的gpcr，这些gpcr最近被证明可以调节它们对心脏损伤的反应。在这篇小型综述中，我们将简要讨论趋化因子受体对白细胞行为的影响，随后关注其他GPCR类对急性心脏损伤后白细胞反应的影响和治疗潜力的最新进展。
Following acute cardiac injury such as myocardial infarction (MI), the controlled activation and recruitment of various leukocytes to the site of tissue damage significantly impacts chronic changes to cardiac structure and function, and ultimately host survival. While recent research has focused primarily on how leukocytes respond to injury, understanding how to effectively modulate their responsiveness to dampen maladaptive inflammation and promote repair processes is not yet fully understood. The complex spatio-temporal migration and activation of leukocytes are largely controlled by various chemokines and their cognate receptors, belonging to the G protein-coupled receptor (GPCR) family. Beyond chemokine receptors, leukocytes express a host of additional GPCRs that have recently been shown to regulate their responsiveness to cardiac injury. In this minireview, we will briefly discuss the impact of chemokine receptors on leukocyte behaviour, with subsequent focus on the most recent advancements in understanding the impact and therapeutic potential of other GPCR classes on leukocyte responses after acute cardiac injury.
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影响因子：
4.6
作者：
Colazzo F;Gelosa P;Tremoli E;Sironi L;Castiglioni L
通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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