Next generation pneumococcal vaccines.
Next generation pneumococcal vaccines.
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DOI：
10.1016/j.coi.2011.04.002
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发表时间：
2011-06
影响因子：
7
通讯作者：
Malley R
中科院分区：
文献类型：
--
作者：
Moffitt KL;Malley R
Currently licensed pneumococcal vaccines are based on the generation of antibodies to the pneumococcal polysaccharide, of which there are more than 90 different types. While these vaccines are highly effective against the serotypes included, their high cost and limited serotype coverage limits their usefulness worldwide, particularly in low resources areas. Thus alternative or adjunctive options are being actively pursued. This review will present these various approaches, including variations of the polysaccharide-protein conjugate strategy, protein-based strategies, and an inactivated whole cell pneumococcal vaccine. The immunological basis for these different approaches is discussed as well.
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DOI：
10.1073/pnas.0501254102
发表时间：
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影响因子：
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作者：
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