Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.
Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.
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DOI：
10.1093/molbev/msab161
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发表时间：
2021-09-27
影响因子：
10.7
通讯作者：
Cheviron ZA
中科院分区：
文献类型：
--
作者：
Schweizer RM;Jones MR;Bradburd GS;Storz JF;Senner NR;Wolf C;Cheviron ZA
当物种在环境梯度上连续分布时，选择和基因流的相对强度会形成遗传变异的空间模式，从而可能导致不同位点之间的差异水平。确定适应性遗传变异是否倾向于在结构上不同于中性变异沿着环境梯度是进化遗传学中的一个开放且重要的问题。我们对沿着海拔梯度近4,000米的垂直地形采样的鹿鼠进行了全外显子组群体基因组分析。通过结合选择扫描、基因型-环境关联和地理渐变群分析，我们发现很大一部分外显子组经历了与海拔高度相关的选择历史。近30%的这些puperian适应基因座的海拔梯度明显上升或下降的梯度的基因座，不承担类似的选择签名。这些选择目标中的许多可以与高地和低地鹿鼠之间已知的表型差异相关联，尽管这些候选者中的绝大多数在高地分类群的其他研究中没有报道。总之，这些结果提出了新的假说的生理适应高海拔的遗传基础，适应性遗传变异的空间分布沿着环境梯度。
When species are continuously distributed across environmental gradients, the relative strength of selection and gene flow shape spatial patterns of genetic variation, potentially leading to variable levels of differentiation across loci. Determining whether adaptive genetic variation tends to be structured differently than neutral variation along environmental gradients is an open and important question in evolutionary genetics. We performed exome-wide population genomic analysis on deer mice sampled along an elevational gradient of nearly 4,000 m of vertical relief. Using a combination of selection scans, genotype−environment associations, and geographic cline analyses, we found that a large proportion of the exome has experienced a history of altitude-related selection. Elevational clines for nearly 30% of these putatively adaptive loci were shifted significantly up- or downslope of clines for loci that did not bear similar signatures of selection. Many of these selection targets can be plausibly linked to known phenotypic differences between highland and lowland deer mice, although the vast majority of these candidates have not been reported in other studies of highland taxa. Together, these results suggest new hypotheses about the genetic basis of physiological adaptation to high altitude, and the spatial distribution of adaptive genetic variation along environmental gradients.
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影响因子：
3.8
作者：
BARTON, NH
通讯作者：
BARTON, NH
影响因子：
4.8
作者：
KNAUS, HG;EBERHART, A;GARCIA, ML
通讯作者：
GARCIA, ML
影响因子：
4.5
作者：
Berg JJ;Coop G
通讯作者：
Coop G
影响因子：
2.8
作者：
Ivy, Catherine M.;Greaves, Mary A.;Scott, Graham R.
通讯作者：
Scott, Graham R.
DOI：
10.1002/joc.1276
发表时间：
2005-12-01
期刊：
INTERNATIONAL JOURNAL OF CLIMATOLOGY
影响因子：
--
作者：
Hijmans, RJ;Cameron, SE;Jarvis, A
通讯作者：
Jarvis, A