Sp1- and Krüppel-like transcription factors.
Sp1- and Krüppel-like transcription factors.
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DOI：
10.1186/gb-2003-4-2-206
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发表时间：
2003
期刊：
影响因子：
12.3
通讯作者：
Urrutia R
中科院分区：
文献类型：
--
作者：
Kaczynski J;Cook T;Urrutia R
sp1样蛋白和kr<s:1> pel样因子（KLFs）是高度相关的锌指蛋白，是真核细胞转录机制的重要组成部分。已经在人类、青蛙、蠕虫和苍蝇中发现了该家族的成员。它们可以作为激活因子或抑制因子发挥作用，这取决于它们结合的启动子和它们相互作用的共调节因子。sp1样蛋白和kr<s:1> pel样因子（KLFs）是高度相关的锌指蛋白，是真核细胞转录机制的重要组成部分。通过调控大量富含gc启动子的基因的表达，sp1样/KLF转录调控因子可能参与细胞功能的几乎所有方面，包括细胞增殖、凋亡、分化和肿瘤转化。sp1样/KLF家族的个体成员可以作为激活因子或抑制因子发挥作用，这取决于它们结合的启动子和它们相互作用的共调节因子。一个长期的研究目标是确定sp1样因子和KLFs以细胞和启动子特异性方式调节基因表达和细胞功能的机制。这个家族的大多数成员已经在哺乳动物中被鉴定出来，在人类基因组中编码了至少21个sp1样/KLF蛋白，在青蛙、蠕虫和苍蝇中也发现了成员。Sp1-like/KLF蛋白具有高度保守的羧基末端锌指结构域，在DNA结合中起作用。含有转录激活域的氨基末端在家族成员之间可能有显著差异。
Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. Members of the family have been identified in humans, frogs, worms and flies. They can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members.
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影响因子：
4.8
作者：
Cook, T;Gebelein, B;Urrutia, R
通讯作者：
Urrutia, R
影响因子：
4.1
作者：
Kaczynski, JA;Conley, AA;Urrutia, R
通讯作者：
Urrutia, R
DOI：
10.1038/nsb1196-940
发表时间：
1996-11-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
--
作者：
Kim, CA;Berg, JM
通讯作者：
Berg, JM
DOI：
10.1073/pnas.91.1.192
发表时间：
1994-01-04
影响因子：
11.1
作者：
GILL, G;PASCAL, E;TJIAN, R
通讯作者：
TJIAN, R
DOI：
10.1073/pnas.93.5.1924
发表时间：
1996-03-05
影响因子：
11.1
作者：
Brown, DD;Wang, Z;Pinder, A
通讯作者：
Pinder, A