Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.
Cerebral metabolism in hypoglycemic and hyperglycemic fetal lambs.
复制标题
低血糖和高血糖胎羔的大脑代谢。
DOI：
10.1152/ajpregu.1983.245.5.r730
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Machida,CM
中科院分区：
文献类型：
--
作者：
Richardson,BS;Hohimer,AR;Bissonnette,JM;Machida,CM
为了研究葡萄糖影响胎儿呼吸运动（FBM）的机制，研究了12只未麻醉的胎儿羔羊，在禁食引起的低血糖期间和随后的胎儿输注葡萄糖后的脑代谢。分析导管动脉和矢状窦血液样本的葡萄糖和氧浓度、血气和ph值。用放射性微球测量局部脑血流量。母亲禁食24 ~ 36 h导致胎儿血糖从1.061 +/- 0.085 mmol X -1降至0.664 +/- 0.053 （P < 0.001）。虽然脑葡萄糖和氧摄取保持不变，但矢状窦CO2分压（Pco2）和[H+]显著降低，这可能是FBM下降的原因。空腹动物胎儿输注葡萄糖2小时，血糖升高至2.452 +/- 0.173 mmol X -1。脑氧消耗再次保持不变；然而，脑葡萄糖消耗显著增加，矢状窦Pco2和[H+]也显著增加，这可能是FBM增加的原因。这些发现与葡萄糖部分通过改变中枢化学感受器环境影响FBM发病率的假设一致。
To investigate the mechanism whereby glucose affects fetal breathing movements (FBM), cerebral metabolism was studied in 12 unanesthetized fetal lambs, during fasting-induced hypoglycemia and after a subsequent fetal infusion of glucose. Preductal arterial and sagittal sinus blood samples were analyzed for glucose and oxygen concentrations and for blood gases and pH. Measurements of regional brain blood flow were made with radioactive microspheres. Maternal fasting of 24- to 36-h duration resulted in a decrease in fetal blood glucose from 1.061 +/- 0.085 mmol X l-1 to 0.664 +/- 0.053 (P less than 0.001). Although cerebral glucose and O2 uptake remained unchanged, sagittal sinus CO2 partial pressure (Pco2) and [H+] were significantly decreased and may have contributed to the observed decrease in FBM. A 2-h infusion of glucose to the fetuses of fasted animals resulted in an increase in blood glucose to 2.452 +/- 0.173 mmol X l-1. Cerebral O2 consumption was again unchanged; however, cerebral glucose consumption was significantly increased as were sagittal sinus Pco2 and [H+], which may have contributed to the observed increase in FBM. These findings are consistent with the hypothesis that glucose affects the incidence of FBM in part by altering the environment of central chemoreceptors.
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影响因子：
33.6
作者：
通讯作者：
--
猫视网膜中的 W 细胞：两个不同类别的相关形态和生理证据。
影响因子：
2.5
作者：
Stanford,LR
通讯作者：
Stanford,LR
DOI：
10.1109/tase.2006.874972
发表时间：
2007-01-01
影响因子：
5.6
作者：
Lee, Kok-Meng;Li, Qiang;Daley, Wayne
通讯作者：
Daley, Wayne
视网膜神经节细胞：特性、类型、属、途径和跨物种比较。
DOI：
10.1159/000121492
发表时间：
1983
期刊：
Brain, behavior and evolution
影响因子：
--
作者：
Rodieck,RW;Brening,RK
通讯作者：
Brening,RK