The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936.
The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936.
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DOI：
10.1186/s13148-017-0438-z
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发表时间：
2018
影响因子：
5.7
通讯作者：
Seniors USP Team
中科院分区：
文献类型：
--
作者：
Gale CR;Marioni RE;Čukić I;Chastin SF;Dall PM;Dontje ML;Skelton DA;Deary IJ;Seniors USP Team
从DNA甲基化模式（被称为表观遗传时钟）得出的生物学年龄估计与死亡率、身体和认知功能以及虚弱有关，但对它们与久坐行为或身体活动的关系知之甚少。我们调查了两种生物学年龄估计之间的横截面关系，并客观地测量了老年人的久坐和步行行为。参与者是1936年洛锡安出生队列的248名成员。在79岁时，使用activPAL活动监测仪测量7天内的久坐行为和身体活动。生物学年龄是使用两种基于DNA甲基化的年龄加速测量来估计的，即，外在和内在表观遗传年龄加速。我们使用线性回归来评估这两种生物学年龄估计值与平均每日久坐时间、从坐到站的转换次数和步数之间的关系。在所研究的六个关联中，只有两个在仅调整年龄和性别的初始模型中具有统计学意义。更大的外在年龄加速与走更少的步数相关（回归系数（95% CI）-0.100（-0.008，-0.001）），更大的内在年龄加速与更多的从坐到站的过渡相关（回归系数（95% CI）0.006（0.0001，0.012））。当我们控制多重统计检验时，这些关联都没有经过校正（P均≥ 0.17）。在这项对79岁老年人的横断面研究中，我们没有发现令人信服的证据表明，生物学年龄（由外在或内在表观遗传年龄加速指数表示）与客观测量的久坐或行走行为相关。
Estimates of biological age derived from DNA-methylation patterns—known as the epigenetic clock—are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behavior and physical activity were measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration—i.e., extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count. Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) − 0.100 (− 0.008, − 0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both P ≥ 0.17). In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behavior.
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全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
5.7
作者：
Nevalainen T;Kananen L;Marttila S;Jylhävä J;Mononen N;Kähönen M;Raitakari OT;Hervonen A;Jylhä M;Lehtimäki T;Hurme M
通讯作者：
Hurme M
影响因子：
4.1
作者：
Matthews CE;Hagströmer M;Pober DM;Bowles HR
通讯作者：
Bowles HR
影响因子：
5.7
作者：
Breitling LP;Saum KU;Perna L;Schöttker B;Holleczek B;Brenner H
通讯作者：
Brenner H
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM