Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury.
Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury.
复制标题
神经损伤后成年小鼠扣带皮锥体神经元内在特性的表征。
DOI：
10.1186/1744-8069-5-73
复制
发表时间：
2009-12-16
期刊：
影响因子：
3.3
通讯作者：
Zhuo M
中科院分区：
文献类型：
--
作者：
Cao XY;Xu H;Wu LJ;Li XY;Chen T;Zhuo M
前扣带皮层（ACC）对认知和感觉功能（包括记忆和慢性疼痛）非常重要。外周损伤后ACC锥体细胞谷氨酸能兴奋性突触传递的长时程增强关于神经元动作电位或内在特性可能的长期变化的信息较少。在本研究中，我们的特点扣带锥体细胞在层II/III的ACC在成年小鼠。然后，我们研究了周围神经损伤后ACC锥体细胞内在特性的可能长期变化。在对照小鼠中，我们发现根据它们的动作电位放电模式，有三种主要类型的锥体细胞：（i）规则尖峰（RS）细胞（24.7%），内在爆发（IB）细胞（30.9%）和中间（IM）细胞（44.4%）。在神经病理性疼痛状态下，这三组小鼠的群体分布（RS：21.3%; IB：31.2%; IM：47.5%）和单个动作电位特性与对照组小鼠无区别。然而，对于重复动作电位，来自神经性疼痛动物的IM细胞显示出更高的初始放电频率，而来自神经性疼痛小鼠的RS和IB神经元的特性没有改变。目前的结果提供了第一个证据，除了以前报道的突触增强，周围神经损伤产生长期的可塑性变化的扣带回锥体神经元的动作电位在细胞类型特异性的方式。
The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we characterized cingulate pyramidal cells in the layer II/III of the ACC in adult mice. We then examined possible long-term changes in intrinsic properties of the ACC pyramidal cells after peripheral nerve injury. In the control mice, we found that there are three major types of pyramidal cells according to their action potential firing pattern: (i) regular spiking (RS) cells (24.7%), intrinsic bursting (IB) cells (30.9%), and intermediate (IM) cells (44.4%). In a state of neuropathic pain, the population distribution (RS: 21.3%; IB: 31.2%; IM: 47.5%) and the single action potential properties of these three groups were indistinguishable from those in control mice. However, for repetitive action potentials, IM cells from neuropathic pain animals showed higher initial firing frequency with no change for the properties of RS and IB neurons from neuropathic pain mice. The present results provide the first evidence that, in addition to synaptic potentiation reported previously, peripheral nerve injury produces long-term plastic changes in the action potentials of cingulate pyramidal neurons in a cell type-specific manner.
登录
查看更多内容
影响因子：
3.3
作者：
Drdla, Ruth;Sandkuehler, Juergen
通讯作者：
Sandkuehler, Juergen
DOI：
10.1073/pnas.96.14.7668
发表时间：
1999-07-06
影响因子：
11.1
作者：
Casey, KL
通讯作者：
Casey, KL
影响因子：
16.2
作者：
Moore, Shannon J.;Cooper, Donald C.;Spruston, Nelson
通讯作者：
Spruston, Nelson
影响因子：
3
作者：
Gan, Huayang;Zhuo, Muning;Zhou, Yongzhang
通讯作者：
Zhou, Yongzhang
影响因子：
3.6
作者：
Cervero, F;Laird, JMA;García-Nicas, E
通讯作者：
García-Nicas, E