JIP3 regulates neuronal radial migration by mediating TrkB axonal anterograde transport in the developing cerebral cortex.
JIP3 regulates neuronal radial migration by mediating TrkB axonal anterograde transport in the developing cerebral cortex.
复制标题
JIP3 通过介导发育中的大脑皮层中的 TrkB 轴突顺行运输来调节神经元径向迁移。
DOI：
10.1016/j.bbrc.2017.02.132
复制
发表时间：
2017
影响因子：
3.1
通讯作者：
Tao Sun
中科院分区：
文献类型：
--
作者：
Huixian Ma;Hui Yu;Ting Li;Yan Zhao;M. Hou;Zheyu Chen;Yue Wang;Tao Sun
径向迁移对于大脑皮质的精确分层和协调功能是必不可少的。然而，神经元径向迁移的分子机制尚不清楚。在这里，我们报道了c-Jun氨基末端激酶(JNK)相互作用蛋白-3(JIP3)在胚胎小鼠的大脑中高表达，并且是放射状迁移所必需的。通过宫内电穿孔敲除JIP3基因，特异性地干扰了皮质神经元的径向迁移，但对神经发生和神经元分化没有影响。此外，我们通过研究JIP3基因敲除的神经元在胚胎和出生后小鼠中的分布，证明了JIP3基因敲除后延缓了皮质神经元的迁移，但不会阻止其迁移。最后，我们发现JIP3在大脑发育过程中通过调节TrkB轴突顺行运输来调节皮质神经元的迁移。这些发现加深了我们对JIP3对神经元发育调控的理解，为我们研究神经元径向迁移的调控机制提供了新的视角。
Radial migration is essential for the precise lamination and the coordinated function of the cerebral cortex. However, the molecular mechanisms for neuronal radial migration are not clear. Here, we report that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) is highly expressed in the brain of embryonic mice and essential for radial migration. Knocking down JIP3 by in utero electroporation specifically perturbs the radial migration of cortical neurons but has no effect on neurogenesis and neuronal differentiation. Furthermore, we illustrate that JIP3 knockdown delays but does not block the migration of cortical neurons by investigating the distribution of neurons with JIP3 knocked down in the embryo and postnatal mouse. Finally, we find that JIP3 regulates cortical neuronal migration by mediating TrkB axonal anterograde transport during brain development. These findings deepen our understanding of the regulation of neuronal development by JIP3 and provide us a novel view on the regulating mechanisms of neuronal radial migration.
影响因子：
3.3
作者：
Chen, ZY;Ieraci, A;Lee, FS
通讯作者：
Lee, FS
影响因子：
19
作者：
Xufeng Wu;Xin Xiang;J. Hammer
通讯作者：
Xufeng Wu;Xin Xiang;J. Hammer