Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors.
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors.
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铜绿假单胞菌：一种具有多种适应性毒力因子的大胆病原体
DOI：
10.3390/ijms22063128
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发表时间：
2021-03-18
影响因子：
5.6
通讯作者：
McClean S
中科院分区：
文献类型：
--
作者：
Jurado-Martín I;Sainz-Mejías M;McClean S
铜绿假单胞菌是囊性纤维化(CF)患者的主要病原体，导致发病率和死亡率。它巨大的适应能力极大地促进了它引起慢性感染的能力。病原体的适应性和灵活性是由其拥有的大量毒力因子提供的，这为铜绿假单胞菌提供了针对环境中不同应激源的反应。深入了解这些毒力机制对于设计针对这种多重耐药病原体的治疗策略和疫苗至关重要。因此，本文综述了铜绿假单胞菌的主要毒力因子及其在恶劣环境中的适应性。巨大的铜绿假单胞菌基因组(5-7MB)对其适应能力有相当大的贡献；因此，基因组研究为阐明铜绿假单胞菌的进化及其在整个感染过程中与宿主的相互作用提供了重要的见解。
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. aeruginosa with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating P. aeruginosa evolution and its interactions with the host throughout the course of infection.
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通讯作者：
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