Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network.

Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network.
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DOI:
10.1038/nprot.2011.372
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发表时间:
2011-08-25
期刊:
影响因子:
14.8
通讯作者:
--
中科院分区:
生物学1区
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--
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AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
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