A Novel Defined PANoptosis-Related miRNA Signature for Predicting the Prognosis and Immune Characteristics in Clear Cell Renal Cell Carcinoma: A miRNA Signature for the Prognosis of ccRCC.
A Novel Defined PANoptosis-Related miRNA Signature for Predicting the Prognosis and Immune Characteristics in Clear Cell Renal Cell Carcinoma: A miRNA Signature for the Prognosis of ccRCC.
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DOI：
10.3390/ijms24119392
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发表时间：
2023-05-28
影响因子：
5.6
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中科院分区：
文献类型：
--
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透明细胞肾细胞癌（ccRCC）是最常见的癌症之一，PANoptosis是一种独特的，由PANoptosome调节的炎症程序性细胞死亡。癌症发生和发展的重要调控因子是microrna (miRNAs)。然而，panoposis相关的microRNAs （PRMs）在ccRCC中的潜在功能尚不清楚。本研究从Cancer Genome Atlas数据库和三个Gene Expression Omnibus数据集中检索ccRCC样本。PRMs是基于先前的科学文献报告而被认可的。采用回归分析确定预后PRMs，并基于风险评分构建panoposis相关miRNA预后标记。通过使用各种R软件包和网络分析工具，我们发现高风险患者的生存预后较差，并且与高级别和晚期肿瘤有显著关联。此外，我们证明了低风险组的代谢途径发生了显著变化。高危组免疫细胞浸润高，免疫检查点表达高，化疗药物半最大抑制浓度（IC50）值低。这表明高危患者可能从免疫治疗和化疗中获益更多。总之，我们构建了panoptosis相关的microRNA特征，揭示了其在临床病理特征和肿瘤免疫中的潜在意义，从而提供了新的精准治疗策略。
Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent cancers, and PANoptosis is a distinct, inflammatory-programmed cell death regulated by the PANoptosome. The essential regulators of cancer occurrence and progression are microRNAs (miRNAs). However, the potential function of PANoptosis-related microRNAs (PRMs) in ccRCC remains obscure. This study retrieved ccRCC samples from The Cancer Genome Atlas database and three Gene Expression Omnibus datasets. PRMs were recognized based on previous reports in the scientific literature. Regression analyses were used to identify the prognosis PRMs and construct a PANoptosis-related miRNA prognostic signature based on the risk score. We discovered that high-risk patients had poorer survival prognoses and were significantly linked to high-grade and advanced-stage tumors, using a variety of R software packages and web analysis tools. Furthermore, we demonstrated that the low-risk group had significant changes in their metabolic pathways. In contrast, the high-risk group was characterized by high immune cell infiltration, immune checkpoint expression, and low half-maximum inhibition concentration (IC50) values of chemotherapeutic agents. This suggests that high-risk patients may benefit more from immunotherapy and chemotherapy. In conclusion, we constructed a PANoptosis-related microRNA signature and revealed its potential significance in clinicopathological features and tumor immunity, thereby providing new precise treatment strategies.
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通讯作者：
Kroemer G