Impacts of breast cancer and chemotherapy on gut microbiome, cognitive functioning, and mood relative to healthy controls.
Impacts of breast cancer and chemotherapy on gut microbiome, cognitive functioning, and mood relative to healthy controls.
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DOI：
10.1038/s41598-022-23793-7
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发表时间：
2022-11-15
影响因子：
4.6
通讯作者：
Lowry, Christopher A.
中科院分区：
文献类型：
--
作者：
Bilenduke, Emily;Sterrett, John D.;Ranby, Krista W.;Borges, Virginia F.;Grigsby, Jim;Carr, Alaina L.;Kilbourn, Kristin;Lowry, Christopher A.
被诊断患有乳腺癌的接受化疗的妇女会出现认知障碍、焦虑和抑郁症状，以及身体副作用，包括肠道微生物群的多样性和群落组成的破坏。到目前为止，探索这些具体挑战之间的联系的研究有限。这项横断面研究探讨了确诊为乳腺癌并接受化疗的女性(BC)与未患癌症的健康对照组(HC)相比，自我报告的认知功能、抑郁和焦虑症状、肠道微生物多样性和群落组成之间的关系。与HC相比，BC组的认知功能障碍(p <； 0.001)和抑郁症状(p <； 0.05)的发生率更高。BC和HC的微生物群落组成存在显著差异，尤其是BC的粘蛋白降解属Akkermansia的相对丰度低于HC(p <； 0.05)。关联模型确定了群体、认知、抑郁和微生物组变量之间的显著关联(p <； 0.001)。总体而言，研究发现，BC参与者在自我报告的认知功能、自我报告的抑郁症状、微生物群落组成以及肠粘膜屏障的粘蛋白降解菌方面与HC有显著差异。本研究与肠道微生物群落组成影响女性乳腺癌和治疗经验的假设一致，表明基于微生物组的干预措施有可能改善乳腺癌患者的生活质量结果。
Women diagnosed with breast cancer undergoing chemotherapy experience cognitive impairment, symptoms of anxiety and depression, and physical side effects including disruption in the diversity and community composition of the gut microbiome. To date, there is limited research exploring the associations among these specific challenges. The present cross-sectional study explored the associations of self-reported cognitive functioning, depression, and anxiety symptoms, and gut microbiome diversity and community composition in women who were diagnosed with and undergoing chemotherapy treatment for breast cancer (BC) compared to cancer-free healthy controls (HC). The BC group displayed higher rates of cognitive dysfunction (p < 0.001) and depressive symptoms (p < 0.05) relative to HC. There was a significant difference in microbiome community composition between BC and HC, particularly characterized by a decreased relative abundance of the mucin-degrading genus Akkermansia in BC compared to HC (p < 0.05). Association models identified significant associations among group, cognitive, depression, and microbiome variables (p < 0.001). Overall, the study identified that BC participants experienced significant differences in self-reported cognitive functioning, self-reported depression symptoms, microbiome community composition, and mucin-degrading bacteria of the gut-mucosal barrier, relative to HC. The present study is consistent with the hypothesis that gut microbiome community composition impacts a woman’s experience with breast cancer and treatment suggesting that microbiome-based interventions have potential for improving quality of life outcomes in individuals with breast cancer.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Chen W;Liu F;Ling Z;Tong X;Xiang C
通讯作者：
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影响因子：
5.9
作者：
Hakansson A;Molin G
通讯作者：
Molin G
影响因子：
6.4
作者：
Amir A;McDonald D;Navas-Molina JA;Debelius J;Morton JT;Hyde E;Robbins-Pianka A;Knight R
通讯作者：
Knight R
DOI：
10.1093/jnci/djy177
发表时间：
2018-12-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Carreira H;Williams R;Müller M;Harewood R;Stanway S;Bhaskaran K
通讯作者：
Bhaskaran K