Moving the Research Forward: The Best of British Biology Using the Tractable Model System Dictyostelium discoideum.

Moving the Research Forward: The Best of British Biology Using the Tractable Model System Dictyostelium discoideum.
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DOI:
10.3390/cells10113036
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发表时间:
2021-11-05
期刊:
影响因子:
6
通讯作者:
Weijer CJ
Weijer CJ
中科院分区:
生物学2区
文献类型:
--
作者:
Williams RSB;Chubb JR;Insall R;King JS;Pears CJ;Thompson E;Weijer CJ

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社会变形虫Dictyostelialdiscoideum为生物学中跨多个学科的研究提供了一个极好的模型。这种有机体大约在10亿年前从植物界、酵母界、真菌界和动物界分化出来,但保留了在这些王国中发现的共同特征。网柄网柄菌具有较低的遗传复杂性,并提供了一系列分子、细胞、生化和发育生物学实验技术,使多学科研究得以在广泛的领域进行,导致研究突破。英国境内的许多实验室都将网柄菌作为其核心研究模型。这篇综述介绍了网柄网柄菌,然后重点介绍了几个英国领先研究实验室的研究,涵盖了他们独特的研究领域,使用该模型的好处,以及由于使用网柄网柄菌作为一种易于处理的模型系统而出现的突破。
The social amoeba Dictyostelium discoideum provides an excellent model for research across a broad range of disciplines within biology. The organism diverged from the plant, yeast, fungi and animal kingdoms around 1 billion years ago but retains common aspects found in these kingdoms. Dictyostelium has a low level of genetic complexity and provides a range of molecular, cellular, biochemical and developmental biology experimental techniques, enabling multidisciplinary studies to be carried out in a wide range of areas, leading to research breakthroughs. Numerous laboratories within the United Kingdom employ Dictyostelium as their core research model. This review introduces Dictyostelium and then highlights research from several leading British research laboratories, covering their distinct areas of research, the benefits of using the model, and the breakthroughs that have arisen due to the use of Dictyostelium as a tractable model system.
DOI: 10.1016/j.ydbio.2005.12.054
发表时间: 2006-04-15
影响因子: 2.7
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