Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: Influence of formulation parameters on Polymethoxyflavone crystallization.
Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: Influence of formulation parameters on Polymethoxyflavone crystallization.
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DOI：
10.1016/j.foodhyd.2011.08.017
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发表时间：
2012-06-01
影响因子：
10.7
通讯作者：
McClements, David Julian
中科院分区：
文献类型：
--
作者：
Li, Yan;Zheng, Jinkai;Xiao, Hang;McClements, David Julian
关键词：
从柑橘皮中提取的多甲氧基黄酮(PMF)具有很强的抗癌活性，但在常温和常温下都是高度疏水的分子，在水和油中的溶解性很差，这限制了它们的生物利用度。研究了将PMF包裹在基于纳米乳液的递送系统中以促进其在保健食品和药品中的应用的可能性。考察了油类型(玉米油、MCT、橙油)、乳化剂类型(β-乳球蛋白、溶血卵磷脂、吐温和DTAB)和中性助溶剂(甘油和乙醇)对PMF纳米乳液形成和稳定性的影响。除了DTAB，所有类型的乳化剂都可以通过高压均质形成纳米乳液(r<；100 nm)。不同的乳化剂类型可以改变脂滴电荷，从高阳离子(DTAB)到近中性(吐温)，再到高度阴离子(β-乳球蛋白、溶血磷脂)。制备后的纳米乳液中均有PMF晶体生成，在储存过程中有沉淀的倾向。PMF晶体的大小、形态和聚集性取决于制备方法、乳化剂类型、油类型和助溶剂加入量。这些结果对开发在应用温度下具有较差油和水溶解性的生物活性成分的输送系统具有重要意义。
Polymethoxyflavones (PMFs) extracted from citrus peel exhibit potent anti-cancer activity, but are highly hydrophobic molecules with poor solubility in both water and oil at ambient and body temperature, which limits their bioavailability. The possibility of encapsulating PMFs within nanoemulsion-based delivery systems to facilitate their application in nutraceutical and pharmaceutical products was investigated. The influence of oil type (corn oil, MCT, orange oil), emulsifier type (β-lactoglobulin, lyso-lecithin, Tween, and DTAB), and neutral cosolvents (glycerol and ethanol) on the formation and stability of PMF-loaded nanoemulsions was examined. Nanoemulsions (r < 100 nm) could be formed using high pressure homogenization for all emulsifier types, except DTAB. Lipid droplet charge could be altered from highly cationic (DTAB), to near neutral (Tween), to highly anionic (β-lactoglobulin, lyso-lecithin) by varying emulsifier type. PMF crystals formed in all nanoemulsions after preparation, which had a tendency to sediment during storage. The size, morphology, and aggregation of PMF crystals depended on preparation method, emulsifier type, oil type, and cosolvent addition. These results have important implications for the development of delivery systems for bioactive components that have poor oil and water solubility at application temperatures.
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影响因子：
5.8
作者：
Ali, W.;Williams, A. C.;Rawlinson, C. F.
通讯作者：
Rawlinson, C. F.
影响因子：
3.8
作者：
Gao, P;Rush, BD;Hageman, MJ
通讯作者：
Hageman, MJ
影响因子：
6.1
作者：
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通讯作者：
Ho, Chi-Tang
DOI：
10.2174/138620710790596781
发表时间：
2010-02-01
影响因子：
1.8
作者：
Hageman, Michael J.
通讯作者：
Hageman, Michael J.
影响因子：
3.3
作者：
Jafari, Seid Mahdi;He, Yinghe;Bhandari, Bhesh
通讯作者：
Bhandari, Bhesh