Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014.
Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014.
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DOI：
10.1007/s13539-014-0164-8
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发表时间：
2014-12
影响因子：
8.9
通讯作者：
Anker, Stefan D.
中科院分区：
文献类型：
--
作者：
von Haehling, Stephan;Anker, Stefan D.
恶病质是许多慢性疾病的严重但被低估的后果。其患病率范围从终末期慢性心力衰竭的5- 15%到晚期癌症的50- 80%。恶病质也是许多慢性肾病、慢性阻塞性肺病（COPD）和类风湿性关节炎患者终末病程的一部分。恶病质患者的死亡率范围从COPD的每年10- 15%到慢性心力衰竭和慢性肾病的每年20- 30%到癌症的每年80%。这种情况还与生活质量差有关。在工业化国家，恶病质的总体患病率（由于任何疾病，不一定与住院有关）正在增长，目前影响约1%的患者人群，即约900万人。在地球仪的其他地方，这也是一个严重的健康问题。最近，我们对该疾病的多因素性质的理解取得了进展，特别是炎症介质的作用和拮抗剂和拮抗剂的不平衡。几种有希望的治疗方法都未能达到III期临床试验的挑战，但生长激素释放肽受体激动剂阿拉莫林似乎已经实现了至少一些早期的承诺。迫切需要取得进一步进展。
Cachexia is a serious but underrecognised consequence of many chronic diseases. Its prevalence ranges from 5–15 % in end-stage chronic heart failure to 50–80 % in advanced cancer. Cachexia is also part of the terminal course of many patients with chronic kidney disease, chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis. Mortality rates of patients with cachexia range from 10–15 % per year in COPD through 20–30 % per year in chronic heart failure and chronic kidney disease to 80 % in cancer. The condition is also associated with poor quality of life. In the industrialised world, the overall prevalence of cachexia (due to any disease and not necessarily associated with hospital admission) is growing and it currently affects around 1 % of the patient population, i.e. around 9 million people. It is also a significant health problem in other parts of the globe. Recently there have been advances in our understanding of the multifactorial nature of the condition, and particularly of the role of inflammatory mediators and the imbalance of anabolism and catabolism. Several promising approaches to treatment have failed to live up to the challenge of phase III clinical trials, but the ghrelin receptor agonist anamorelin seems to have fulfilled at least some early promise. Further advances are urgently needed.
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影响因子：
39.3
作者：
Fuelster, Susann;Tacke, Matthias;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
2.7
作者：
Mauri, Davide;Tsiara, Anna;Polyzos, Nikolaos P.
通讯作者：
Polyzos, Nikolaos P.
卡希克西亚是主要被低估和未满足的医疗需求：事实和数字。
影响因子：
8.9
作者：
von Haehling, Stephan;Anker, Stefan D.
通讯作者：
Anker, Stefan D.
影响因子：
24
作者：
Melenovsky, Vojtech;Kotrc, Martin;Kautzner, Josef
通讯作者：
Kautzner, Josef
影响因子：
3.7
作者：
Bourdel-Marchasson I;Blanc-Bisson C;Doussau A;Germain C;Blanc JF;Dauba J;Lahmar C;Terrebonne E;Lecaille C;Ceccaldi J;Cany L;Lavau-Denes S;Houede N;Chomy F;Durrieu J;Soubeyran P;Senesse P;Chene G;Fonck M
通讯作者：
Fonck M