Editing and Chemical Modifications on Non-Coding RNAs in Cancer: A New Tale with Clinical Significance.
Editing and Chemical Modifications on Non-Coding RNAs in Cancer: A New Tale with Clinical Significance.
复制标题
DOI：
10.3390/ijms22020581
复制
发表时间：
2021-01-08
影响因子：
5.6
通讯作者：
Calin GA
中科院分区：
文献类型：
--
作者：
Torsin LI;Petrescu GED;Sabo AA;Chen B;Brehar FM;Dragomir MP;Calin GA
Currently, for seemingly every type of cancer, dysregulated levels of non-coding RNAs (ncRNAs) are reported and non-coding transcripts are expected to be the next class of diagnostic and therapeutic tools in oncology. Recently, alterations to the ncRNAs transcriptome have emerged as a novel hallmark of cancer. Historically, ncRNAs were characterized mainly as regulators and little attention was paid to the mechanisms that regulate them. The role of modifications, which can control the function of ncRNAs post-transcriptionally, only recently began to emerge. Typically, these modifications can be divided into reversible (i.e., chemical modifications: m5C, hm5C, m6A, m1A, and pseudouridine) and non-reversible (i.e., editing: ADAR dependent, APOBEC dependent and ADAR/APOBEC independent). The first research papers showed that levels of these modifications are altered in cancer and can be part of the tumorigenic process. Hence, the aim of this review paper is to describe the most common regulatory modifications (editing and chemical modifications) of the traditionally considered “non-functional” ncRNAs (i.e., microRNAs, long non-coding RNAs and circular RNAs) in the context of malignant disease. We consider that only by understanding this extra regulatory layer it is possible to translate the knowledge about ncRNAs and their modifications into clinical practice.
登录
查看更多内容
影响因子：
29.4
作者：
Chen B;Dragomir MP;Fabris L;Bayraktar R;Knutsen E;Liu X;Tang C;Li Y;Shimura T;Ivkovic TC;De Los Santos MC;Anfossi S;Shimizu M;Shah MY;Ling H;Shen P;Multani AS;Pardini B;Burks JK;Katayama H;Reineke LC;Huo L;Syed M;Song S;Ferracin M;Oki E;Fromm B;Ivan C;Bhuvaneshwar K;Gusev Y;Mimori K;Menter D;Sen S;Matsuyama T;Uetake H;Vasilescu C;Kopetz S;Parker-Thornburg J;Taguchi A;Hanash SM;Girnita L;Slaby O;Goel A;Varani G;Gagea M;Li C;Ajani JA;Calin GA
通讯作者：
Calin GA
影响因子：
4.7
作者：
Bai, Yang;Yang, Chunxing;Zhang, Yi
通讯作者：
Zhang, Yi
影响因子：
14.9
作者：
Cesarini V;Silvestris DA;Tassinari V;Tomaselli S;Alon S;Eisenberg E;Locatelli F;Gallo A
通讯作者：
Gallo A
影响因子：
7
作者：
Bánfai B;Jia H;Khatun J;Wood E;Risk B;Gundling WE Jr;Kundaje A;Gunawardena HP;Yu Y;Xie L;Krajewski K;Strahl BD;Chen X;Bickel P;Giddings MC;Brown JB;Lipovich L
通讯作者：
Lipovich L
影响因子：
2.7
作者：
Cheng X;Chen J;Huang Z
通讯作者：
Huang Z