miR-372 promotes breast cancer cell proliferation by directly targeting LATS2.
miR-372 promotes breast cancer cell proliferation by directly targeting LATS2.
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DOI：
10.3892/etm.2018.5761
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发表时间：
2018-03
影响因子：
2.7
通讯作者：
Huang Z
中科院分区：
文献类型：
--
作者：
Cheng X;Chen J;Huang Z
MicroRNAs (miRs) have previously been demonstrated to be important in the tumorigenesis and progression of breast cancer. miR-372 was previously revealed to be involved in various types of human cancer, however its function in breast cancer remains largely unknown. The present study demonstrated that miR-372 is frequently overexpressed in breast cancer cell lines and tissues. The downregulation of miR-372 markedly inhibited cell proliferation, arrested the cell cycle in the G1/S phase, and increased the apoptosis of breast cancer cells. Consistently, an in vivo xenograft study also demonstrated the suppressive effects of miR-372 knockdown on tumor growth. Further studies revealed that miR-372 modulated the expression of large tumor suppressor kinase 2 (LATS2) by directly targeting its 3′-untranslated region in breast cancer cells. Furthermore, silencing of LATS2 was able to rescue the effect of the miR-372 inhibitor. Overall, the results suggest that miR-372 functions as an oncogenic miRNA in breast cancer by targeting LATS2.
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DOI：
10.4161/cc.8.22.10033
发表时间：
2009-11-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Qi J;Yu JY;Shcherbata HR;Mathieu J;Wang AJ;Seal S;Zhou W;Stadler BM;Bourgin D;Wang L;Nelson A;Ware C;Raymond C;Lim LP;Magnus J;Ivanovska I;Diaz R;Ball A;Cleary MA;Ruohola-Baker H
通讯作者：
Ruohola-Baker H
影响因子：
3.7
作者：
Ke, HN;Pei, J;Tao, WF
通讯作者：
Tao, WF
影响因子：
64.8
作者：
Britschgi A;Duss S;Kim S;Couto JP;Brinkhaus H;Koren S;De Silva D;Mertz KD;Kaup D;Varga Z;Voshol H;Vissieres A;Leroy C;Roloff T;Stadler MB;Scheel CH;Miraglia LJ;Orth AP;Bonamy GM;Reddy VA;Bentires-Alj M
通讯作者：
Bentires-Alj M
影响因子：
3.7
作者：
Hu J;Guo H;Li H;Liu Y;Liu J;Chen L;Zhang J;Zhang N
通讯作者：
Zhang N
影响因子：
30.8
作者：
Bentwich, I;Avniel, A;Bentwich, Z
通讯作者：
Bentwich, Z