Serum transforming growth factor-beta1 levels in bone marrow transplant recipients correlate with blood cell counts and chronic graft-versus-host disease.
Serum transforming growth factor-beta1 levels in bone marrow transplant recipients correlate with blood cell counts and chronic graft-versus-host disease.
复制标题
骨髓移植受者的血清转化生长因子-β1 水平与血细胞计数和慢性移植物抗宿主病相关。
作者：
Linda Liem;Wim E. Fibbe;H. van Houwelingen;Els Goulmy
OBJECTIVE
Profound immunosuppression and extensive fibrotic changes in the skin are characteristic for graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT). Transforming growth factor (TGF)-beta is a potent immunosuppressive cytokine that plays an important regulatory role in the immune response. In addition, TGF-beta promotes wound repair but has also been implicated in tissue fibrosis. These characteristics prompted us to question whether serum TGF-beta levels would be associated with GVHD after BMT.
METHODS
In this study, total TGF-beta1 levels in serum from HLA-identical BMT recipients before and at several time intervals after transplantation were quantified and correlated with platelet and white blood cell (WBC) counts and with the presence of acute and chronic GVHD in a multivariate analysis.
RESULTS
TGF-beta1 levels were readily detectable in healthy controls and in BMT recipients before BMT. In all patients, a rapid drop in TGF-beta1 levels was seen during the BMT conditioning regimen. After 20-50 days postBMT, TGF-beta1 levels started to increase to normal levels. Platelet and WBC counts were strongly correlated with TGF-beta1 levels (r=0.810, P<0.001, and r=0.733, P<0.001, respectively). Multivariate analysis also revealed that TGF-beta1 levels were significantly increased during chronic GVHD and that the increase during acute GVHD reached levels of significance (P=0.009 and P=0.053, respectively).
CONCLUSIONS
These results show that total TGF-beta1 levels correlate significantly with platelet and WBC counts and that chronic GVHD is associated with an increase in serum TGF-beta1, independent of platelet or WBC counts.
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影响因子：
3.4
作者：
ANSCHER, MS;CROCKER, IR;JIRTLE, RL
通讯作者：
JIRTLE, RL
DOI：
10.1172/jci114964
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
S. Phan;M. Gharaee-Kermani;Frances W. Wolber;Una S. Ryan
通讯作者：
S. Phan;M. Gharaee-Kermani;Frances W. Wolber;Una S. Ryan
转化生长因子 β 1 共刺激葡萄球菌肠毒素 B 反应性 CD8 T 细胞的生长和调节功能。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rich,S;Seelig,M;Lee,HM;Lin,J
通讯作者：
Lin,J
DOI：
--
发表时间：
1988-08
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
D. Hoyt;J. Lazo
通讯作者：
D. Hoyt;J. Lazo
II期乳腺癌高剂量化疗后血浆转化生长因子β的变化：对预防肝静脉闭塞性疾病和肺部药物毒性的可能影响。
DOI：
--
发表时间：
1995
期刊：
Bone marrow transplantation.
影响因子：
--
作者：
Murase,T;Anscher,MS;Petros,WP;Peters,WP;Jirtle,RL
通讯作者：
Jirtle,RL