Can CD147 work as a therapeutic target for tumors through COVID-19 infection?
Can CD147 work as a therapeutic target for tumors through COVID-19 infection?
复制标题
DOI：
10.7150/ijms.79162
复制
发表时间：
2022
影响因子：
3.6
通讯作者：
Xia P
中科院分区：
文献类型：
--
作者：
Ren HL;Wen GM;Zhao ZY;Liu DH;Xia P
In this review, we discussed an interesting case infected with “COVID-19” (Corona Virus Disease 2019). The patients with Hodgkin's lymphoma recovered after infection with COVID-19. It may be that COVID-19 activates the patient's immune system, or it may be a coincidence. COVID-19 spike protein can interact with CD147 and use it as an entry to invade host cells. CD147 is a partner of SLC3A2, which is the chaperone subunit of cystine/glutamate reverse transporter (system XC). The catalytic subunit of system XC is SLC7A11. SLC7A11 mediated cysteine uptake plays a key role in ferroptosis. Through literature review and data analysis, we suggest that CD147, as a new potential COVID-19 infection entry, may also lead to ferroptosis of host cells. Our hypothesis is that spike protein of COVID-19 induced ferroptosis in host cells via CD147/SLC3A2/SLC7A11 complex. This is another explanation for the cancer patient recovered after COVID-19 infection.
登录
查看更多内容
影响因子：
3.7
作者：
Bougatef F;Menashi S;Khayati F;Naïmi B;Porcher R;Podgorniak MP;Millot G;Janin A;Calvo F;Lebbé C;Mourah S
通讯作者：
Mourah S
影响因子：
4.3
作者：
Lai, Tat-Ming;Kuo, Po-Jan;Fu, Earl
通讯作者：
Fu, Earl
影响因子：
3.7
作者：
Li, Fang;Zhang, Junping;Wang, Zhuanhua
通讯作者：
Wang, Zhuanhua
影响因子：
64.8
作者：
Jiang, Le;Kon, Ning;Li, Tongyuan;Wang, Shang-Jui;Su, Tao;Hibshoosh, Hanina;Baer, Richard;Gu, Wei
通讯作者：
Gu, Wei
配体亲环蛋白A和受体CD147增加与舌鳞状细胞癌缺氧、血管生成、转移和预后的关系
影响因子：
6.4
作者：
Huang, Congfa;Sun, Zhijun;Zhang, Wenfeng
通讯作者：
Zhang, Wenfeng