Comparisons Among Optical Coherence Tomography and Fundus Autofluorescence Modalities as Measurements of Atrophy in ABCA4-Associated Disease.
Comparisons Among Optical Coherence Tomography and Fundus Autofluorescence Modalities as Measurements of Atrophy in ABCA4-Associated Disease.
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DOI：
10.1167/tvst.11.1.36
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发表时间：
2022-01-03
影响因子：
3
通讯作者：
Sparrow JR
中科院分区：
文献类型：
--
作者：
Parmann R;Tsang SH;Zernant J;Allikmets R;Greenstein VC;Sparrow JR
在ABCA 4相关视网膜病变中，通过光谱域光学相干断层扫描（SD-OCT）以及短波长（SW-AF）和近红外（NIR-AF）自体荧光评估中心萎缩。患者表现出中央萎缩性病变，其特征为两个AF图像中的低自体荧光（hypoAF）被高自体荧光（hyperAF）环包围（第1组，4例患者）;或SW-AF中的hyperAF环，但在NIR-AF图像中没有（第2组，11例患者）;或两个AF图像中的hyperAF环（第3组，11例患者）。在中央凹SD-OCT扫描中测量脉络膜过度透射和椭圆区（EZ）丢失宽度，在AF图像中，沿同一轴沿着测量hypo+hyperAF宽度。采用Bland-Altman和重复测量方差分析及Tukey事后分析。对于所有组，超传输宽度显着小于EZ损失宽度。在组1和组2中，超透射宽度与SW-hypoAF宽度无显著差异，但超透射宽度窄于SW-hypo +hyperAF（组1，2）和NIR-hypo +hyperAF（组1）的宽度。在第3组中，超透射宽度也显著小于SW-hypoAF和NIR-hypoAF的宽度。EZ损失宽度与总病变大小的测量值无显著差异，后者是SW-低+高AF和NIR-低+高AF的宽度（第1组）; NIR-低AF和SW-低+高AF的宽度（第2组）;以及NIR-低AF和SW-低AF的宽度（第3组）。超透射和SW-hypoAF（除非反映总病变宽度）低估了EZ丢失、SW-hypoAF +hyperAF和NIR-hypo +hyperAF检测到的病变大小。研究结果对临床研究中结局指标的选择具有重要意义。
In ABCA4-associated retinopathy, central atrophy was assessed by spectral domain optical coherence tomography (SD-OCT) and by short-wavelength (SW-AF) and near-infrared (NIR-AF) autofluorescence. Patients exhibited a central atrophic lesion characterized by hypoautofluorescence (hypoAF) surrounded either by hyperautofluorescent (hyperAF) rings in both AF images (group 1, 4 patients); or a hyperAF ring in SW-AF but not in NIR-AF images (group 2, 11 patients); or hyperAF rings in neither AF images (group 3, 11 patients). Choroidal hypertransmission and widths of ellipsoid zone (EZ) loss were measured in foveal SD-OCT scans, and in AF images hypoAF and total hypo+hyperAF widths were measured along the same axis. Bland-Altman and repeated measures analysis of variance with Tukey post hoc were applied. For all groups, hypertransmission widths were significantly smaller than EZ loss widths. In Groups 1 and 2, hypertransmission width was not significantly different than SW-hypoAF width, but hypertransmission was narrower than the width of SW-hypo+hyperAF (groups 1, 2) and NIR-hypo+hyperAF (group 1). In group 3, the hypertransmission width was also significantly less than the width of SW-hypoAF and NIR-hypoAF. The EZ loss widths were not significantly different than measurements of total lesion size, the latter being the widths of SW-hypo+hyperAF and NIR-hypo+hyperAF (group 1); widths of NIR-hypoAF and SW-hypo+hyperAF (group 2); and widths of NIR-hypoAF and SW-hypoAF (group 3). Hypertransmission and SW-hypoAF (except when reflecting total lesion width) underestimate lesion size detected by EZ loss, SW-hypoAF+hyperAF, and NIR-hypo+hyperAF. The findings are significant to the selection of outcome measures in clinical studies.
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影响因子：
3.7
作者：
Lambertus S;Bax NM;Fakin A;Groenewoud JM;Klevering BJ;Moore AT;Michaelides M;Webster AR;van der Wilt GJ;Hoyng CB
通讯作者：
Hoyng CB
影响因子：
13.7
作者：
Kong, Xiangrong;Strauss, Rupert W.;Scholl, Hendrik P. N.
通讯作者：
Scholl, Hendrik P. N.
影响因子：
4.4
作者：
Greenstein VC;Nunez J;Lee W;Schuerch K;Fortune B;Tsang SH;Allikmets R;Sparrow JR;Hood DC
通讯作者：
Hood DC
影响因子：
4.4
作者：
Burke, Tomas R.;Duncker, Tobias;Delori, Francois C.
通讯作者：
Delori, Francois C.
影响因子：
4.2
作者：
Paavo M;Lee W;Allikmets R;Tsang S;Sparrow JR
通讯作者：
Sparrow JR