A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease.
A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease.
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DOI：
10.1167/iovs.17-22532
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发表时间：
2017-10-01
影响因子：
4.4
通讯作者：
Hood DC
中科院分区：
文献类型：
--
作者：
Greenstein VC;Nunez J;Lee W;Schuerch K;Fortune B;Tsang SH;Allikmets R;Sparrow JR;Hood DC
比较隐性Stargardt病（STGD 1）中宽视场扫频源光学相干断层扫描（ssOCT）获得的正面图像与短波长自体荧光（SW-AF）和近红外（NIR）-AF上的低和高自体荧光（hypoAF，hyperAF）区域的形态学变化。从16名患者（16只眼）中获得宽视野ssOCT立方体扫描。使用Spectralis HRA+ OCT获得平均B扫描和SW-AF图像。6只眼获得NIR-AF图像。分割内/外段（IS/OS）、OS/RPE和RPE/Bruch膜边界，并生成正面平板图像。使用subRPE平板图像测量异常RPE面积，使用IS/OS平板图像测量IS/OS结损失面积。将这些与低和异常SW-AF区域以及低NIR-AF区域进行比较。视网膜前色素上皮（OS）平板图像被用来评估空间和视网膜内的位置的flopes。对于所有的眼睛，RPE萎缩可视化为subRPE板上的中央高反射区，IS/OS连接丢失为IS/OS板上的异常反射区;后者明显更大（P = 0.04）。亚RPE平板图像上的高反射区与hypoSW-AF区之间以及IS/OS平板上的异常反射区与hypo-hyperSW-AF区之间具有良好的一致性; hypoNIR-AF区表明亚RPE平板上的高反射区低估了RPE萎缩。正面前RPE（OS）板片图像上的超反射闪烁的空间位置与SW-AF图像上的超反射闪烁的空间位置相对应。宽视野正面OCT成像有可能成为治疗STGD 1的临床有用工具。
To compare morphologic changes on en face images derived from wide-field swept-source optical coherence tomography (ssOCT) to hypo- and hyperautofluorescent (hypoAF, hyperAF) areas on short-wavelength autofluorescence (SW-AF), and near-infrared (NIR)-AF in recessive Stargardt disease (STGD1). Wide-field ssOCT cube scans were obtained from 16 patients (16 eyes). Averaged B-scans and SW-AF images were obtained using Spectralis HRA+OCT. NIR-AF images were obtained from 6 eyes. The inner/outer segment (IS/OS), OS/RPE, and RPE/Bruch's membrane boundaries were segmented, and en face slab images generated. A subRPE slab image was used to measure the abnormal RPE area, and an IS/OS slab image, the IS/OS junction loss area. These were compared to hypo- and abnormal SW-AF areas, and hypoNIR-AF areas. A preRPE(OS) slab image was used to evaluate the spatial and intraretinal locations of flecks. For all eyes, RPE atrophy was visualized as a central hyperreflective area on the subRPE slab, and IS/OS junction loss as an abnormal reflective area on the IS/OS slab; the latter was significantly larger (P = 0.04). There was good agreement between the hyperreflective area on the subRPE slab image and hypoSW-AF area, and between the abnormal reflective area on the IS/OS slab and hypo-hyperSW-AF area; the hypoNIR-AF area indicated that the hyperreflective area on the subRPE slab underestimated RPE atrophy. The spatial locations of hyperreflective flecks on the en face preRPE(OS) slab image corresponded to those on the SW-AF images. Wide-field en face OCT imaging has the potential to be a clinically useful tool for the management of STGD1.
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影响因子：
4.4
作者：
Burke, Tomas R.;Rhee, David W.;Greenstein, Vivienne C.
通讯作者：
Greenstein, Vivienne C.
影响因子：
4.4
作者：
Burke, Tomas R.;Duncker, Tobias;Delori, Francois C.
通讯作者：
Delori, Francois C.
Stargardt疾病患者的眼底自动荧光和视网膜结构的比较。
影响因子：
4.4
作者：
Gomes NL;Greenstein VC;Carlson JN;Tsang SH;Smith RT;Carr RE;Hood DC;Chang S
通讯作者：
Chang S
影响因子：
4.4
作者：
Duncker, Tobias;Marsiglia, Marcela;Sparrow, Janet R.
通讯作者：
Sparrow, Janet R.
影响因子：
3.9
作者：
Cornelis, Stephanie S.;Bax, Nathalie M.;Cremers, Frans P. M.
通讯作者：
Cremers, Frans P. M.