Action Potential Collision in Heart Tissue-Computer Simulations and Tissue Expenrments
Action Potential Collision in Heart Tissue-Computer Simulations and Tissue Expenrments
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心脏组织计算机模拟和组织实验中的动作电位碰撞
DOI：
10.1109/tbme.1985.325488
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发表时间：
1985
影响因子：
4.6
通讯作者：
S. Isomura
中科院分区：
文献类型：
--
作者：
B. Steinhaus;K. Spitzer;S. Isomura
通过一维动作电位传播的计算机模拟和组织实验，研究了动作电位碰撞对心脏浦肯野和乳头肌的电效应。与正常单向传播相比，碰撞的影响包括所有测量的动作电位上升和复极指标的定量变化。这些变化可以归因于膜净电流的时空变化。参数敏感性和分析技术确定了五个因素来决定碰撞引起的动作电位面积的减少：传导速度、动作电位高度、电缆半径、细胞内比电阻率和动作电位复极时的比膜电阻。模拟结果表明，碰撞效应与动作电位时程的不均一性无关，碰撞效应的空间范围大于被动空间常数，某些模拟的异常情况(如不连续传播、组织缺血)增加了碰撞效应的大小。组织实验支持关于直接在碰撞部位和在碰撞部位两侧的动作电位构型变化的模拟。升高的[K+]0增加了两种组织制剂中动作电位时程的变化。在乳头肌中，横向的碰撞效应比纵向的碰撞效应局限在更窄的区域内，变化的峰值幅度没有差异。动作电位碰撞是心脏常见的现象。
The electrical effects of action potential collision were studied using a computer simulation of one-dimensional action potential propagation and tissue experiments from isolated cardiac Purkinje strands and papillary muscles. The effects of collision, when compared to normal one-way propagation, included quantitative changes in all of the measured indexes of action potential upstroke and repolarization. These changes can be attributed to spatiotemporal changes in the net membrane current. Parameter sensitivity and analytic techniques identified five factors which determine the collision-induced decrease in action potential area: conduction velocity, action potential height, cable radius, specific intracellular resistivity, and the specific membrane resistance during action potential repolarization. The simulations demonstrated that collision effects were independent of inhomogeneity in action potential duration, the spatial extent of the collision effects was greater than the passive space constant, and certain simulated abnormal conditions (e. g., discontinuous propagation, ischemic tissue) increased the magnitude of the collision effects. The tissue experiments supported the simulations regarding the changes in action potential configuration directly at and on each side of the collision site. Elevated [K+]0 increased the changes in action potential duration in both tissue preparations. In papillary muscles, collision effects in the transverse direction were confined to a narrower region than collision effects in the longitudinal direction with no difference in the peak magnitude of the changes. Action potential collision is a common occurrence in the heart.
影响因子：
3.4
作者：
G. H. Sharp;R. W. Joyner
通讯作者：
G. H. Sharp;R. W. Joyner