Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.
Adoption of Organ Preservation and Surgeon Variability for Patients with Rectal Cancer Does Not Correlate with Worse Survival.
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直肠癌患者采用器官保存和外科医生的变化与较差的生存率无关。
DOI：
10.1245/s10434-021-10877-3
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发表时间：
2022-03
影响因子：
3.7
通讯作者：
Garcia-Aguilar J
中科院分区：
文献类型：
--
作者：
Kim JK;Thompson H;Jimenez-Rodriguez RM;Wu F;Sanchez-Vega F;Nash GM;Guillem JG;Paty PB;Wei IH;Pappou EP;Widmar M;Weiser MR;Smith JJ;Garcia-Aguilar J
Watch-and-wait is variably adopted by surgeons and the impact of this on outcomes is unknown. We compare the disease-free survival and organ preservation rates of locally advanced rectal cancer patients treated by expert colorectal surgeons at a comprehensive cancer center. This study included retrospective data on patients diagnosed with stage II/III rectal adenocarcinoma from January 2013 to June 2017 who initiated neoadjuvant therapy (either with chemoradiation, chemotherapy, or a combination of both) and were treated by an expert colorectal surgeon. 444 locally advanced rectal cancer patients managed by 5 surgeons were included. Tumor distance from the anal verge, type of neoadjuvant therapy, and organ preservation rates varied by treating surgeon. There was no difference in disease-free survival after stratifying by the treating surgeon (p=0.2). On multivariable analysis, neither the type of neoadjuvant therapy nor the treating surgeon was associated with disease-free survival. While neoadjuvant therapy type and organ preservation rates varied among surgeons, there were no meaningful differences in disease-free survival. These data suggest that amongst expert colorectal surgeons, differing thresholds for selecting patients for watch-and-wait do not affect survival.
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影响因子：
3.7
作者：
Felder SI;Patil S;Kennedy E;Garcia-Aguilar J
通讯作者：
Garcia-Aguilar J
影响因子：
2.6
作者：
Caycedo-Marulanda, Antonio;Patel, Sunil, V;Mayol, Julio
通讯作者：
Mayol, Julio
DOI：
10.6004/jnccn.2020.0032
发表时间：
2020-07-01
影响因子：
13.4
作者：
Benson, Al B., III;Venook, Alan P.;Gurski, Lisa A.
通讯作者：
Gurski, Lisa A.
影响因子：
28.4
作者：
Cercek, Andrea;Roxburgh, Campbell S. D.;Weiser, Martin R.
通讯作者：
Weiser, Martin R.
影响因子：
5.9
作者：
Beets-Tan RGH;Lambregts DMJ;Maas M;Bipat S;Barbaro B;Curvo-Semedo L;Fenlon HM;Gollub MJ;Gourtsoyianni S;Halligan S;Hoeffel C;Kim SH;Laghi A;Maier A;Rafaelsen SR;Stoker J;Taylor SA;Torkzad MR;Blomqvist L
通讯作者：
Blomqvist L