Heart Failure and Patient-Reported Outcomes in Adults With Congenital Heart Disease from 15 Countries.
Heart Failure and Patient-Reported Outcomes in Adults With Congenital Heart Disease from 15 Countries.
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来自15个国家的成人先天性心脏病患者的心力衰竭及患者报告结局
DOI：
10.1161/jaha.121.024993
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发表时间：
2022-05-03
影响因子：
5.4
通讯作者：
Moons, Philip
中科院分区：
文献类型：
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作者：
Lu, Chun-Wei;Wang, Jou-Kou;Yang, Hsiao-Ling;Kovacs, Adrienne H.;Luyckx, Koen;Ruperti-Repilado, Francisco Javier;Van de Bruaene, Alexander;Enomoto, Junko;Sluman, Maayke A.;Jackson, Jamie L.;Khairy, Paul;Cook, Stephen C.;Chidambarathanu, Shanthi;Alday, Luis;Oechslin, Erwin;Eriksen, Katrine;Dellborg, Mikael;Berghammer, Malin;Johansson, Bengt;Mackie, Andrew S.;Menahem, Samuel;Caruana, Maryanne;Veldtman, Gruschen;Soufi, Alexandra;Fernandes, Susan M.;White, Kamila;Callus, Edward;Kutty, Shelby;Apers, Silke;Moons, Philip
心力衰竭（HF）是成人先天性心脏病患者死亡的主要原因，并与显著的发病率相关。我们试图评估成人先天性心脏病患者HF与患者报告结局之间的相关性。作为APPROACH-IS（成人先天性心脏病患者报告结局模式评估-国际研究）的一部分，我们收集了来自5大洲15个国家的3959例患者的HF状态和患者报告结局数据。患者报告结局为：感知健康状况（12项简明健康调查表）、生活质量（线性焦虑量表和生活满意度量表）、一致性感-13、心理困扰（医院焦虑和抑郁量表）和疾病感知（简明疾病感知问卷）。在该样本中，137例（3.5%）在研究时患有HF，298例（7.5%）有HF病史，3524例（89.0%）当前或既往无HF发作。当前或既往HF患者年龄较大，复杂先天性心脏病、心律失常、植入式心脏复律器、其他临床合并症和情绪障碍的患病率高于从未患有HF的患者。HF患者的身体功能、心理功能、生活质量、生活满意度、连贯性、抑郁症状和疾病感知评分均较差。身体功能和疾病感知的差异幅度较大，而心理功能、生活质量和抑郁症状的差异幅度适中。先天性心脏病成人患者的HF与患者报告的结局较差相关，身体功能和疾病感知的效应量较大。URL：https://clinicaltrials.gov;唯一标识符：NCT 02150603。
Heart failure (HF) is the leading cause of mortality and associated with significant morbidity in adults with congenital heart disease. We sought to assess the association between HF and patient‐report outcomes in adults with congenital heart disease. As part of the APPROACH‐IS (Assessment of Patterns of Patient‐Reported Outcomes in Adults with Congenital Heart disease—International Study), we collected data on HF status and patient‐reported outcomes in 3959 patients from 15 countries across 5 continents. Patient‐report outcomes were: perceived health status (12‐item Short Form Health Survey), quality of life (Linear Analogue Scale and Satisfaction with Life Scale), sense of coherence‐13, psychological distress (Hospital Anxiety and Depression Scale), and illness perception (Brief Illness Perception Questionnaire). In this sample, 137 (3.5%) had HF at the time of investigation, 298 (7.5%) had a history of HF, and 3524 (89.0%) had no current or past episode of HF. Patients with current or past HF were older and had a higher prevalence of complex congenital heart disease, arrhythmias, implantable cardioverter‐defibrillators, other clinical comorbidities, and mood disorders than those who never had HF. Patients with HF had worse physical functioning, mental functioning, quality of life, satisfaction with life, sense of coherence, depressive symptoms, and illness perception scores. Magnitudes of differences were large for physical functioning and illness perception and moderate for mental functioning, quality of life, and depressive symptoms. HF in adults with congenital heart disease is associated with poorer patient‐reported outcomes, with large effect sizes for physical functioning and illness perception. URL: https://clinicaltrials.gov; Unique identifier: NCT02150603.
影响因子：
3.6
作者：
Callus E;Pagliuca S;Boveri S;Ambrogi F;Luyckx K;Kovacs AH;Apers S;Budts W;Enomoto J;Sluman MA;Wang JK;Jackson JL;Khairy P;Cook SC;Chidambarathanu S;Alday L;Eriksen K;Dellborg M;Berghammer M;Johansson B;Mackie AS;Menahem S;Caruana M;Veldtman G;Soufi A;Fernandes SM;White K;Kutty S;Moons P;APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD)
通讯作者：
APPROACH-IS consortium and the International Society for Adult Congenital Heart Disease (ISACHD)