Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system.
Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system.
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DOI：
10.1186/1475-2859-5-13
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发表时间：
2006-03-23
影响因子：
6.4
通讯作者：
Oliveira SC
中科院分区：
文献类型：
--
作者：
Cardoso PG;Macedo GC;Azevedo V;Oliveira SC
布鲁氏菌是兼性细胞内病原体，能够在专职和非专职吞噬细胞中生存和繁殖，并导致家畜流产和人类波浪热。布鲁氏菌属内有几个种，这种分类主要基于致病性和宿主偏好的差异。布鲁氏菌菌株可以以光滑或粗糙的形式存在，表达光滑LPS（S-LPS）或粗糙LPS（R-LPS）作为主要表面抗原。这种细菌具有非传统的非内毒素脂多糖，赋予抵抗抗微生物攻击和调节宿主免疫反应。对人类致病的菌株（B. abortus，牛种B. suis，B. melitensis）携带与这些细菌的毒力有关的光滑LPS。LPS O-链保护细菌免受细胞阳离子肽、氧代谢产物和补体介导的裂解，并且它是布鲁氏菌在宿主中存活和复制的关键分子。本文综述了布鲁氏菌LPS的结构、布鲁氏菌基因组、LPS生物合成相关基因、LPS与先天免疫的相互作用。
Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. Several species are recognized within the genus Brucella and this classification is mainly based on the difference in pathogenicity and in host preference. Brucella strains may occur as either smooth or rough, expressing smooth LPS (S-LPS) or rough LPS (R-LPS) as major surface antigen. This bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks and modulates the host immune response. The strains that are pathogenic for humans (B. abortus, B. suis, B. melitensis) carry a smooth LPS involved in the virulence of these bacteria. The LPS O-chain protects the bacteria from cellular cationic peptides, oxygen metabolites and complement-mediated lysis and it is a key molecule for Brucella survival and replication in the host. Here, we review i) Brucella LPS structure; ii) Brucella genome, iii) genes involved in LPS biosynthesis; iv) the interaction between LPS and innate immunity.
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影响因子：
3.1
作者：
Campos, MA;Rosinha, GMS;Oliveira, SC
通讯作者：
Oliveira, SC
影响因子：
3.1
作者：
Allen, CA;Adams, LG;Ficht, TA
通讯作者：
Ficht, TA
DOI：
10.1073/pnas.221575398
发表时间：
2002-01-08
影响因子：
11.1
作者：
DelVecchio, VG;Kapatral, V;Overbeek, R
通讯作者：
Overbeek, R
影响因子：
5.8
作者：
Cloeckaert, A;Verger, JM;Godfroid, J
通讯作者：
Godfroid, J
影响因子：
4.4
作者：
Huang, LY;Ishii, KJ;Golding, B
通讯作者：
Golding, B