Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transportedPhaseolus vulgaris leucoagglutinin
Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transportedPhaseolus vulgaris leucoagglutinin
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顺行运输的菜豆白细胞凝集素揭示的大细胞基底核细分的皮质投射模式
DOI：
10.1016/0006-8993(87)91014-6
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
D. Spencer
中科院分区：
文献类型：
--
作者：
P. Luiten;R. Gaykema;J. Traber;D. Spencer
本文详细分析了大鼠大细胞基底核（MBN）和布洛卡斜带水平肢（HDB）的皮质投射。用顺行示踪剂phaseolus vulgarisleuco凝集素（PHA-L）离子电泳注射MBN和HDB。对标记的传出神经进行免疫细胞化学可视化后，光镜下研究了投射物在皮层套、嗅觉区和杏仁核上的分布。基于皮质投影模式的差异，MBN被细分为前、中、后部分（MBNa、MBNi和MBNp）。所有的细分都保持着新皮层的投射，并服从于前后的地形安排。然而，在整个模式中，额叶皮层是主要目标。此外，所有的MBN部分都投射到中皮层和外皮层的各个区域，随着示踪剂注射的时间越早，这些区域的密度越高。然而，最明显的发现是当PHA-L注射部位从后向前移动时，腹外侧到背内侧的皮质投影模式。因此，后部MBN主要投射到外侧新皮层和中皮层，而前部MBN向内侧皮层区域发送更多的纤维。此外，MBN是嗅觉核大量传入输入的来源，因此应被视为向HDB的过渡。HDB除了密集地投射到嗅球和相关核外，还保持大量输出到内侧前额皮质区和内嗅皮质。年轻和老年病例的比较表明，年龄似乎对皮质神经支配模式没有深刻的影响，至少在用PHA-L方法研究时是这样。
The present paper deals with a detailed analysis of cortical projections from the magnocellular basal nucleus (MBN) and horizontal limb of the diagonal band of Broca (HDB) in the rat. The MBN and HDB were injected iontophoretically with the anterograde tracerPhaseolus vulgarisleucoagglutinin (PHA-L). After immunocytochemical visualization of labeled efferents, the distribution of projections over the cortical mantle, olfactory regions and amygdala were studied by light microscopy. Based on differences in cortical projection patterns, the MBN was subdivided in anterior, intermediate and posterior portions (MBNa, MBNi and MBNp). All subdivisions maintain neocortical projections and are subject to an anterior to posterior topographic arrangement. In the overall pattern, however, the frontal cortex is the chief target. Furthermore, all MBN parts project to various regions of meso- and allocortex, which are progressively more dense when the tracer injection is more anteriorly plaed. The most conspicuous finding, however, was a ventrolateral to dorsomedial cortical projection pattern as the PHA-L injection site moved from posterior to anterior. Thus, the posterior MBN projects predominantly to lateral neo- and mesocortex while the anterior MBN sends more fibers to the medial cortical regions. Furthermore, the MBN is a source of considerable afferent input to the olfactory nuclei and as such should be regarded as a transition to the HDB. The HDB, apart from projecting densely to olfactory bulb and related nuclei, maintains a substantial output to the medial prefrontal cortical regions and entorhinal cortex, as well. Comparison of young vs aged cases indicate that aging does not appear to have a profound influence on cortical innervation patterns, at least as studied with the PHA-L method.
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR