The Role of Toll-Like Receptor in Inflammation and Tumor Immunity.
The Role of Toll-Like Receptor in Inflammation and Tumor Immunity.
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Toll样受体在炎症和肿瘤免疫中的作用
DOI：
10.3389/fphar.2018.00878
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发表时间：
2018
影响因子：
5.6
通讯作者：
Cheng K
中科院分区：
文献类型：
--
作者：
Cen X;Liu S;Cheng K
Toll样受体(Toll-like Receptor，TLRs)的激活使宿主能够识别大量的病原体相关分子模式(PAMPs)，激发免疫细胞区分自体和异体，进而促进以下先天和获得性免疫反应。越来越多的临床/临床前证据表明，TLRs在自身免疫性疾病中起着关键作用，包括炎症性疾病和肿瘤相关疾病。TLRs的激活正在成为或已经成为癌症治疗的靶点。结果表明，TLRs通过诱导炎性细胞因子表达和细胞毒性T淋巴细胞(CTL)应答，具有较好的抗肿瘤作用。作为佐剂，TLRs激动剂可以启动强大的免疫反应，辅助肿瘤放射治疗和生物化疗。另一方面，肿瘤相关抗原作为PAMP，也可以激活TLRs，诱导肿瘤基因相关的程序性细胞死亡，包括细胞凋亡、自噬和程序性坏死。同时也有观点认为，TLRs的过度表达将促进各种生物的肿瘤恶化，因为TLR诱导的炎症将加速肿瘤细胞在肿瘤微环境(TME)中的提升。然而，TLRs对癌症的作用至今仍不十分清楚。本文综述了TLRs在肿瘤治疗中的最新研究进展及其在TME中的作用，并对其未来发展进行了展望。
Toll-like receptors (TLRs) activation enables host to recognize a large number of pathogen-associated molecule patterns (PAMPs), ignite immune cells to discriminate between self and non-self, and then promote the following innate and adaptive immune responses. Accumulated clinical/preclinical evidences have proven TLRs to be critical role in the autoimmune diseases, including inflammatory and tumor-associated diseases. Activation of TLRs is becoming or has been a target for cancer treatment. It is shown that TLRs can induce preferable anti-tumor effect by eliciting inflammatory cytokines expression and cytotoxic T lymphocytes (CTLs) response. As adjuvant, TLRs agonists can launch a strong immune response to assist cancer radiotherapy and bio-chemotherapy. On the other hand, tumor-associated antigens acting as PAMPs, can also activate TLRs and induce tumor gene-related programmed cell death, including apoptosis, autophagy and programmed necrosis. While there are also arguments that the excessive TLRs expression will promote tumor deterioration in various organisms, as the TLR-induced inflammation will accelerate the cancer cells boost in the tumor microenvironment (TME). However, the effect of TLRs acting on cancers is still not quite clear today. In this review, we will summarize the recent researches of TLRs in cancer treatment and their role in TME, giving a brief overview on future expectation.
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影响因子：
7.2
作者：
Labidi-Galy SI;Treilleux I;Goddard-Leon S;Combes JD;Blay JY;Ray-Coquard I;Caux C;Bendriss-Vermare N
通讯作者：
Bendriss-Vermare N
影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
影响因子：
5.6
作者：
Grimmig T;Moench R;Kreckel J;Haack S;Rueckert F;Rehder R;Tripathi S;Ribas C;Chandraker A;Germer CT;Gasser M;Waaga-Gasser AM
通讯作者：
Waaga-Gasser AM
影响因子：
5.4
作者：
Heufler, C;Koch, F;Schuler, G
通讯作者：
Schuler, G
影响因子：
4.4
作者：
Hancz, Dora;Szabo, Aniko;Koncz, Gabor
通讯作者：
Koncz, Gabor