Associative regulation of Pavlovian fear conditioning: unconditional stimulus intensity, incentive shifts, and latent inhibition.
Associative regulation of Pavlovian fear conditioning: unconditional stimulus intensity, incentive shifts, and latent inhibition.
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巴甫洛夫恐惧条件的联想调节：无条件刺激强度、激励转变和潜在抑制。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
M. Fanselow
中科院分区：
文献类型：
--
作者：
S. L. Young;M. Fanselow
条件刺激（CS）与疼痛的无条件刺激（US）相关，产生纳洛酮可逆镇痛。镇痛作为恐惧条件反射的负反馈调节，可以解释US强度和CS预测性对巴甫洛夫恐惧条件反射的影响。在实验1中，纳洛酮下的训练产生的学习曲线接近相同的高渐近线，尽管美国的强度。在采集过程中改变药物治疗的效果会导致超声强度发生变化。在实验3中，纳洛酮使用上下文CS逆转了Hall-Pearce（1979）的负转移，表明在CS-弱-足电击阶段获得的条件性镇痛延迟了CS-强-足电击阶段的获得。实验5在潜伏抑制和负迁移过程中都使用了声调CS。纳洛酮仅阻断负传递。因此，负迁移而不是潜伏抑制是由US处理的减少介导的。
Conditional stimuli (CS) associated with painful unconditional stimuli (US) produce a naloxone-reversible analgesia. The analgesia serves as a negative-feedback regulation of fear conditioning that can account for the impact of US intensity and CS predictiveness on Pavlovian fear conditioning. In Experiment 1 training under naloxone produced learning curves that approached the same high asymptote despite US intensity. Shifting drug treatment during acquisition had effects that paralleled US intensity shifts. In Experiment 3 naloxone reversed Hall-Pearce (1979) negative transfer using a contextual CS, indicating that conditional analgesia acquired during the CS-weak-footshock phase retards acquisition in the CS-strong-footshock phase. Experiment 5 used a tone CS in both a latent-inhibition and a negative-transfer procedure. Only negative transfer was blocked by naloxone. Therefore, negative transfer but not latent inhibition is mediated by a reduction of US processing.
阿片拮抗剂可改善空间记忆。
DOI：
10.1126/science.6879198
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gallagher,M;King,RA;Young,NB
通讯作者：
Young,NB
内侧间隔区阿片类药物微注射对大鼠空间记忆的影响。
影响因子：
1.9
作者：
Bostock,E;Gallagher,M;King,RA
通讯作者：
King,RA