Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease.
Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease.
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DOI：
10.1002/dvdy.22046
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发表时间：
2010-01
影响因子：
2.5
通讯作者：
Zorn, Aaron M.
中科院分区：
文献类型：
--
作者：
Kormish, Jay D.;Sinner, Debora;Zorn, Aaron M.
SOX家族的转录因子已经在不同的发育和疾病背景中作为经典Wnt/β-连环蛋白信号传导的调节剂出现。脊椎动物基因组中编码有超过20种SOX蛋白，最近的证据表明，这些蛋白中的许多蛋白可以与β-连环蛋白物理相互作用并调节Wnt靶基因的转录。SOX蛋白调节β-连环蛋白/TCF活性的确切机制仍在研究中，有证据支持许多模型，包括：蛋白质-蛋白质相互作用、SOX因子与Wnt靶基因启动子的结合、辅阻遏物或辅激活物的募集、蛋白质稳定性的调节和核转位。在某些情况下，Wnt信号传导还调节SOX表达，导致反馈调节环，其微调对β-连环蛋白/TCF活性的细胞应答。在这篇综述中，我们总结了Sox-Wnt相互作用的例子，并研究了这种潜在的广泛传播和低估的Wnt调控模式的潜在机制。
The SOX family of transcription factors have emerged as modulators of canonical Wnt/β-catenin signaling in diverse development and disease contexts. There are over twenty SOX proteins encoded in the vertebrate genome and recent evidence suggests that many of these can physically interact with β-catenin and modulate the transcription of Wnt-target genes. The precise mechanisms by which SOX proteins regulate β-catenin/TCF activity are still being resolved and there is evidence to support a number of models including; protein-protein interactions, the binding of SOX factors to Wnt-target gene promoters, the recruitment of co-repressors or co-activators, modulation of protein stability and nuclear translocation. In some contexts Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine tune cellular responses to β-catenin/TCF activity. In this review we summarize the examples of Sox-Wnt interactions and examine the underlying mechanisms of this potentially wide spread and underappreciated mode of Wnt-regulation.
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DOI：
10.1083/jcb.200311021
发表时间：
2004-07-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blache P;van de Wetering M;Duluc I;Domon C;Berta P;Freund JN;Clevers H;Jay P
通讯作者：
Jay P
影响因子：
1.7
作者：
Dong, C;Wilhelm, D;Koopman, P
通讯作者：
Koopman, P
影响因子：
10.5
作者：
Akiyama, H;Chaboissier, MC;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
影响因子：
3.5
作者：
Chassot, Anne-Amandine;Ranc, Fariba;Chaboissier, Marie-Christine
通讯作者：
Chaboissier, Marie-Christine
影响因子：
11.2
作者：
Aaboe, M;Birkenkamp-Demtroder, K;Orntoft, T
通讯作者：
Orntoft, T