Severe hemolytic disease of a newborn due to anti-E combined with anti-Mia, anti-Mur and anti-Hil
Severe hemolytic disease of a newborn due to anti-E combined with anti-Mia, anti-Mur and anti-Hil
复制标题
抗E联合抗Mia、抗Mur、抗Hil致新生儿严重溶血病
DOI：
10.21037/aob-21-35
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Yanli Ji
中科院分区：
文献类型：
--
作者：
Ling Wei;Yew-Wah Liew;Brett Wilson;Aiqun Huang;Jizhi Wen;Zhen Wang;Guangping Luo;Yanli Ji
背景：导致胎儿和新生儿严重溶血性疾病(HDFN)的常见同种异体抗体在不同种族之间可能有所不同。Mns血型杂交血型血型杂交型血糖蛋白GP.Mur在东南亚地区分布频率较高。抗GP的同种异体抗体(抗‘Mi a’)通常是几种低频抗原的抗体的混合物。在本研究中，我们首先描述了广州地区一例重型HDFN，中国，它是由抗E同种异体抗体和GP特异性引起的。Mi a，Mur和Hil。方法：对新生儿和父母的血液标本进行抗体筛查和鉴定分析，然后进行Gyp*Mur基因分型。同时对新生儿进行直接抗球蛋白试验(DAT)和淋洗试验。结果：母亲为B组，CcDee，Mur−，父亲为B组，ccDEE，Mur+，新生儿为B组，CcDe，Mur+。基因分型结果显示，母亲没有Gyp*Mur，而父亲和新生儿携带杂合子Gyp*Mur等位基因。新生儿DAT试验抗-Ig G强阳性。母体血清和新生儿淋洗液中均检出抗E抗体和抗‘Mi a’抗体，而新生儿血清中仅检出抗E抗体。进一步鉴定抗Mi a的特异性为抗Mi a、抗Mur和抗hIL的组合。结论：由于GP.Mur同种异体抗体可导致严重的HDFN，强烈建议在抗体筛选细胞中加入GP.Mur红细胞，以避免东南亚人群中同种异体抗体的漏检。
Background: Common alloantibodies leading to severe hemolytic disease of the fetus and newborn (HDFN) could vary among different ethnic groups. The MNS blood group hybrid glycophorin GP.Mur distributes with a high frequency in the regions of Southeast Asia. Alloantibodies against GP.Mur (anti-‘Mi a ’) often present as mixture of antibodies against several low frequency antigens. In this study, we first described a case of severe HDFN in Guangzhou, China, which was caused by alloantibodies of anti-E in combination with specificities to the GP.Mur including Mi a , Mur and Hil. Methods: Blood samples from the newborn boy and parents have been subjected to antibody screening and identification analysis followed by GYP*Mur genotyping. The direct antiglobulin test (DAT) and the eluate technique were also performed for the newborn. Results: The mother was group B, CCDee, Mur−, the father was group B, ccDEE, Mur+, and the newborn was group B, CcDEe, Mur+. Genotyping results showed the mother was absent for GYP*Mur , while the father and the newborn carried heterozygous GYP*Mur allele. DAT test of the newborn was strongly positive with anti-IgG. Anti-E and anti-‘Mi a ’ were detected in the maternal serum and the newborn’s eluate, whereas anti-E alone was detected in the newborn’s serum. The anti-‘Mi a ’ specificity was further identified as combination of anti-Mi a , anti-Mur and anti-Hil. Conclusions: Because alloantibodies to GP.Mur could cause severe HDFN, it is highly recommended to include GP.Mur red cells in antibody screening cells to avoid miss detection of the alloantibodies in the populations of Southeast Asia.
登录
查看更多内容
影响因子：
1.5
作者：
Kang-Hsi Wu;Jan‐Gowth Chang;M. Lin;M. Shih;Hung-Chih Lin;C. C. Lee-C.;C. Peng;C. Tsai
通讯作者：
Kang-Hsi Wu;Jan‐Gowth Chang;M. Lin;M. Shih;Hung-Chih Lin;C. C. Lee-C.;C. Peng;C. Tsai
影响因子：
1.5
作者：
C.‐A. Yang;J-A Lin;C.‐W. Chang;Kang-Hsi Wu;Shih-Peng Yeh;C. Ho;J.‐G. Chang
通讯作者：
C.‐A. Yang;J-A Lin;C.‐W. Chang;Kang-Hsi Wu;Shih-Peng Yeh;C. Ho;J.‐G. Chang
影响因子：
2.9
作者：
Wei, Ling;Lopez, Genghis H.;Ji, Yanli
通讯作者：
Ji, Yanli
DOI：
10.1515/jpm.2009.071
发表时间：
2009-07
期刊：
--
影响因子：
--
作者：
S. Waldvogel;J. Natterer;G. Canellini;A. Truttmann;J. Tissot
通讯作者：
S. Waldvogel;J. Natterer;G. Canellini;A. Truttmann;J. Tissot
DOI：
10.1111/j.1365-2257.1996.tb00731.x
发表时间：
2010-09
期刊：
Clinical and laboratory haematology
影响因子：
--
作者：
C. K. Lin;K. Mak;S. Szeto;K. Poon;C. Yuen;N. K. Chan;H. W. Liu;C. Ng
通讯作者：
C. K. Lin;K. Mak;S. Szeto;K. Poon;C. Yuen;N. K. Chan;H. W. Liu;C. Ng