Mst1 and Mst2 kinases: regulations and diseases.
Mst1 and Mst2 kinases: regulations and diseases.
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Mst1 和 Mst2 激酶：调节和疾病。
DOI：
10.1186/2045-3701-3-31
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发表时间：
2013-08-28
影响因子：
7.5
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Qin F;Tian J;Zhou D;Chen L
Hippo信号通路已成为器官大小控制的关键调节因子。丝氨酸/苏氨酸蛋白激酶Mst 1和Mst 2是来自果蝇的Hippo激酶的哺乳动物同源物，在发育期间控制细胞增殖、分化和凋亡的Hippo途径中发挥核心作用。Mst 1/2可以被细胞应激物激活，并且Mst 1/2的激活可能通过几种机制执行反馈刺激系统来调节氧化剂水平，其中细胞氧化还原状态的调节可能代表Mst 1/2的肿瘤抑制功能。在果蝇中，鼠Mst 1/Mst 2，在一个冗余的方式，负调控Yorkie直系同源雅普在多个器官，虽然相当大的多样化的途径组成和调节中观察到的一些。通常，Mst 1和Mst 2两者的缺失导致过度增殖和肿瘤发生，这可以通过雅普的减少或消除而在很大程度上被抵消。Hippo信号通路与其他信号通路如Wnt和Notch信号通路整合并相互协调，共同影响肿瘤的发生和发展。此外，Mst 1/2激酶还在免疫细胞活化、粘附、迁移、生长和凋亡中充当重要调节剂。本文就Mst 1/2激酶在这些方面的研究进展作一综述。
The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development. Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2. As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them. Generally, loss of both Mst1 and Mst2 results in hyperproliferation and tumorigenesis that can be largely negated by the reduction or elimination of YAP. The Hippo pathway integrates with other signaling pathways e.g. Wnt and Notch pathways and coordinates with them to impact on the tumor pathogenesis and development. Furthermore, Mst1/2 kinases also act as an important regulator in immune cell activation, adhesion, migration, growth, and apoptosis. This review will focus on the recent updates on those aspects for the roles of Mst1/2 kinases.
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影响因子：
3.7
作者：
Crequer A;Picard C;Patin E;D'Amico A;Abhyankar A;Munzer M;Debré M;Zhang SY;de Saint-Basile G;Fischer A;Abel L;Orth G;Casanova JL;Jouanguy E
通讯作者：
Jouanguy E
DOI：
10.1126/science.1199010
发表时间：
2011-04-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Heallen T;Zhang M;Wang J;Bonilla-Claudio M;Klysik E;Johnson RL;Martin JF
通讯作者：
Martin JF
影响因子：
4.8
作者：
Creasy, CL;Ambrose, DM;Chernoff, J
通讯作者：
Chernoff, J
影响因子：
7.3
作者：
Avruch, Joseph;Zhou, Dawang;Fitamant, Julien;Bardeesy, Nabeel;Mou, Fan;Barrufet, Laura Regue
通讯作者：
Barrufet, Laura Regue
影响因子：
4.6
作者：
Kango-Singh, M;Nolo, R;Halder, G
通讯作者：
Halder, G