Biological perspectives of delayed fracture healing.
Biological perspectives of delayed fracture healing.
复制标题
DOI：
10.1016/j.injury.2014.04.003
复制
发表时间：
2014-06
影响因子：
2.5
通讯作者：
Marcucio, R.
中科院分区：
文献类型：
--
作者：
Hankenson, K. D.;Zimmerman, G.;Marcucio, R.
骨折愈合是一个复杂的生物学过程，需要一系列不同细胞类型之间的相互作用。保持适当的时间进展和空间模式对于实现稳健的愈合至关重要。我们可以通过基因表达，蛋白质分析，组织学或非侵入性地使用生物标志物以及成像技术来暂时评估生物相。然而，确定是什么导致正常与异常愈合更具挑战性。由于骨折愈合过程的最终结果是恢复骨的原始功能，因此骨折愈合的评估不仅应包括监测结构和力学功能的恢复，而且还应评估正常骨生物学的恢复。目前很少有愈合生物学的非侵入性措施;然而，最近的研究表明，非侵入性措施与人类骨折愈合结果相关，血清TGF β 1水平似乎是愈合与不愈合的指标。在未来，开发额外的血清措施来评估生物愈合将提高可靠性，并允许我们评估骨折愈合的阶段。此外，新的功能成像技术可以证明有助于更好地了解人类患者的正常骨折愈合和预测功能障碍愈合。
Fracture healing is a complex biological process that requires interaction among a series of different cell types. Maintaining the appropriate temporal progression and spatial pattern is essential to achieve robust healing. We can temporally assess the biological phases via gene expression, protein analysis, histologically, or non-invasively using biomarkers as well as imaging techniques. However, determining what leads to normal verses abnormal healing is more challenging. Since the ultimate outcome of the process of fracture healing is to restore the original functions of bone, assessment of fracture healing should include not only monitoring the restoration of structure and mechanical function, but also an evaluation of the restoration of normal bone biology. Currently very few non-invasive measures of the biology of healing exist; however, recent studies that have correlated non-invasive measures with fracture healing outcome in humans have shown that serum TGFbeta1 levels appear to be an indicator of healing vs non-healing. In the future, developing additional serum measures to assess biological healing will improve the reliability and permit us to assess stages of fracture healing. Additionally, new functional imaging technologies could prove useful for better understanding both normal fracture healing and predicting dysfunctional healing in human patients.
登录
查看更多内容
影响因子：
3.7
作者：
Dishowitz MI;Mutyaba PL;Takacs JD;Barr AM;Engiles JB;Ahn J;Hankenson KD
通讯作者：
Hankenson KD
影响因子：
5.2
作者：
Grcevic, Danka;Pejda, Slavica;Matthews, Brya G.;Repic, Dario;Wang, Liping;Li, Haitao;Kronenberg, Mark S.;Jiang, Xi;Maye, Peter;Adams, Douglas J.;Rowe, David W.;Aguila, Hector L.;Kalajzic, Ivo
通讯作者：
Kalajzic, Ivo
影响因子：
5.5
作者：
Merceron, Christophe;Vinatier, Claire;Guicheux, Jerome
通讯作者：
Guicheux, Jerome
影响因子：
6.2
作者：
Alexander, Kylie A.;Chang, Ming K.;Pettit, Allison R.
通讯作者：
Pettit, Allison R.
影响因子：
4.6
作者：
Amarilio, Roy;Viukov, Sergey V.;Zelzer, Elazar
通讯作者：
Zelzer, Elazar