Effects of a yoga-based stress reduction intervention on stress, psychological outcomes and cardiometabolic biomarkers in cancer caregivers: A randomized controlled trial.
Effects of a yoga-based stress reduction intervention on stress, psychological outcomes and cardiometabolic biomarkers in cancer caregivers: A randomized controlled trial.
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DOI：
10.1371/journal.pone.0277009
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Ross, Alyson
中科院分区：
文献类型：
--
作者：
Lee, Lena J.;Shamburek, Robert;Son, Hyojin;Wallen, Gwenyth R.;Cox, Robert;Flynn, Sharon;Yang, Li;Bevans, Margaret;Wehrlen, Leslie;Ross, Alyson
护理压力是心脏代谢疾病的危险因素。因此，将心脏代谢生物标志物整合到心脏病研究中可以更全面地评估个体的健康状况和对干预措施的反应。本研究的目的是检查基于瑜伽的减压干预对癌症护理人员的压力，心理结果和心脏代谢生物标志物的影响。这项前瞻性随机对照试验招募了在美国国立卫生研究院（NIH）临床中心接受同种异体HSCT的成年患者的家庭护理人员。所有受试者均接受常规护理教育。干预组的参与者接受了为期六周的艾扬格瑜伽干预，使用录音文件进行自我管理。主要结果是感知压力（使用NIH工具箱感知压力测量）。次要结果是心理因素（使用PROMIS®抑郁和焦虑测量的抑郁和焦虑），以及通过核磁共振波谱测量的心脏代谢生物标志物。共有50名家庭照顾者（平均[SD]年龄，44.9 [15.2]岁; 42名[84.0%]女性）被随机分配，其中25名分配到干预组，25名分配到对照组。在压力、抑郁和焦虑方面没有发现组间差异。在大TRL-P（F（1，43）= 10.16，p = 0.003）和LP-IR（F（1，42）= 4.28，p = 0.045）中发现组和时间之间的显著交互作用。事后分析显示，大TRL-P水平（平均差异= 1.68，CI = [0.86，2.51]，p< .001）和LP-IR（平均差异= 5.67，CI = [1.15，10.18]，p = 0.015）在对照组中随时间显著增加，但在干预组中保持稳定（平均差异=-0.15，CI = [-0.96，0.66]，p = 0.718;平均差异=-0.81，CI = [-5.22，3.61]，p = 0.714）。即使对心理困扰的看法保持不变，结合温和的瑜伽姿势和呼吸练习可能会通过抑制胰岛素抵抗的发展来降低护理人员患心脏代谢疾病的风险。心脏代谢风险的标准脂质似乎不足以检测护理人员心脏代谢风险的短期早期变化。试验注册：ClinicalTrials.gov标识符：NCT 02257853。
Caregiving stress is a risk factor for cardiometabolic disease. Therefore, integrating cardiometabolic biomarkers into caregiving research provides a more comprehensive assessment of an individual’s health and response to an intervention. The objective of this study was to examine the effects of a yoga-based stress reduction intervention on stress, psychological outcomes, and cardiometabolic biomarkers in cancer caregivers. This prospective randomized controlled trial enrolled family caregivers of adult patients who underwent an allogeneic HSCT at the National Institutes of Health (NIH) Clinical Center. All subjects received usual care education. Participants in the intervention group received an Iyengar yoga intervention self-administered over six weeks using an audio recording file. The primary outcome was perceived stress (measured using the NIH toolbox Perceived Stress). The secondary outcomes were psychological factors (depression and anxiety measured using PROMIS® Depression and Anxiety), and cardiometabolic biomarkers measured by nuclear magnetic resonance spectroscopy. A total of 50 family caregivers (mean [SD] age, 44.9 [15.2] years; 42 [84.0%] women) were randomized, 25 to the intervention group and 25 to the control group. No group differences were noted in stress, depression, and anxiety. Significant interaction effects between group and time were found in large TRL-P (F(1,43) = 10.16, p = 0.003) and LP-IR (F(1,42) = 4.28, p = 0.045). Post-hoc analyses revealed that the levels of large TRL-P (mean difference = 1.68, CI = [0.86, 2.51], p< .001) and LP-IR (mean difference = 5.67, CI = [1.15, 10.18], p = 0.015) significantly increased over time in the control group but while remained stable in the intervention group (mean difference = -0.15, CI = [-0.96, 0.66], p = 0.718; mean difference = -0.81, CI = [-5.22, 3.61], p = 0.714, respectively). Even when perceptions of psychological distress remain unchanged, incorporating gentle yoga poses and breathing exercises may reduce the risk of cardiometabolic disease in caregivers by inhibiting the development of insulin resistance. Standard lipids of cardiometabolic risk do not appear to be robust enough to detect short-term early changes of cardiometabolic risk in caregivers. Trial registration: ClinicalTrials.gov Identifier: NCT02257853.
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DOI：
10.1177/1049909119862254
发表时间：
2020-02
期刊：
The American journal of hospice & palliative care
影响因子：
--
作者：
Johns SA;Beck-Coon K;Stutz PV;Talib TL;Chinh K;Cottingham AH;Schmidt K;Shields C;Stout ME;Stump TE;Monahan PO;Torke AM;Helft PR
通讯作者：
Helft PR
影响因子：
4.9
作者：
Butzer, Bethany;LoRusso, Amanda;Shin, Sunny H.;Khalsa, Sat Bir S.
通讯作者：
Khalsa, Sat Bir S.
影响因子：
2.8
作者：
Gupta V;Raj M;Hoodin F;Yahng L;Braun T;Choi SW
通讯作者：
Choi SW
影响因子：
2.7
作者：
Mochari-Greenberger, Heidi;Mosca, Lori
通讯作者：
Mosca, Lori
影响因子：
9.8
作者：
Goff, DC;D'Agostino, RB;Otvos, JD
通讯作者：
Otvos, JD