Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women.
Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women.
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DOI：
10.1007/s10552-009-9321-3
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发表时间：
2009-09
影响因子：
2.3
通讯作者：
Lampe, Johanna W.
中科院分区：
文献类型：
--
作者：
Yong, Mellissa;Atkinson, Charlotte;Newton, Katherine M.;Bowles, Erin J. Aiello;Stanczyk, Frank Z.;Westerlind, Kim C.;Holt, Victoria L.;Schwartz, Stephen M.;Leisenring, Wendy M.;Lampe, Johanna W.
乳腺X线摄影乳腺和骨密度（BMD）与绝经前妇女的黄体期激素浓度有关。我们评估了绝经前妇女乳腺和骨密度与卵泡期激素和性激素结合球蛋白（SHBG）的相关性，因为卵泡期激素已被证明与绝经前乳腺癌风险呈正相关。192名40-45岁的女性在卵泡期提供了点尿和/或血液样本。测量激素和SHBG浓度和骨密度，并访问常规乳房X线照片并数字化以获得乳房密度测量值。拟合回归模型以评估激素和SHBG与乳腺和骨密度之间的关联。在控制体重指数（BMI）、怀孕次数和母乳喂养史后，观察到乳腺密度百分比与SHBG（p趋势= 0.02）以及雌二醇（p趋势= 0.08）之间存在正相关性。此外，在控制BMI后，观察到总睾酮和头部BMD之间存在统计学显著负相关（p趋势= 0.01）。在月经周期的卵泡期，观察到乳房和骨密度与血清激素浓度之间存在关联。
Mammographic breast and bone mineral densities (BMD) have been associated with luteal phase hormone concentrations in premenopausal women. We assessed the associations of breast and bone densities with follicular phase hormones and sex hormone binding globulin (SHBG) in premenopausal women given that follicular phase hormones have been shown to be positively associated with premenopausal breast cancer risk. One hundred and ninety two 40-45 year old women provided a spot urine and/or blood sample during the follicular phase. Hormone and SHBG concentrations and bone density were measured and routine mammograms were accessed and digitized to obtain breast density measures. Regression models were fit to assess the associations between hormones and SHBG and breast and bone densities. Positive associations were observed between percent breast density and SHBG (p trend = 0.02), as well as estradiol (p trend = 0.08), after controlling for body mass index (BMI), number of pregnancies, and breast feeding history. In addition, a statistically significant inverse association was observed between total testosterone and head BMD (p trend = 0.01), after controlling for BMI. Associations were observed between breast and bone densities and serum hormone concentrations during the follicular phase of the menstrual cycle.
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影响因子：
1.9
作者：
Liberman, L;Menell, JH
通讯作者：
Menell, JH
影响因子：
120.7
作者：
Cauley, JA;Lucas, FL;Cummings, SR
通讯作者：
Cummings, SR
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
8.8
作者：
Boyd, NF;Stone, J;Martin, LJ;Jong, R;Fishel, E;Yaffe, M;Hammond, G;Minkin, S
通讯作者：
Minkin, S
影响因子：
5.8
作者：
Finkelstein, JS;Lee, MLT;Greendale, GA
通讯作者：
Greendale, GA