The association of breast mitogens with mammographic densities.
The association of breast mitogens with mammographic densities.
复制标题
DOI：
10.1038/sj.bjc.6600537
复制
发表时间：
2002-10-07
影响因子：
8.8
通讯作者：
Minkin, S
中科院分区：
文献类型：
--
作者：
Boyd, NF;Stone, J;Martin, LJ;Jong, R;Fishel, E;Yaffe, M;Hammond, G;Minkin, S
放射学上致密的乳腺组织（乳房X线照相密度）与乳腺癌风险密切相关，但这种关联的生物学基础尚不清楚。在这项研究中，我们检查了激素和生长因子的循环水平与乳房X光密度的关系。共有 382 名受试者，其中 193 名绝经前受试者和 189 名绝经后受试者，从乳房 X 光检查单位的乳腺密度的五个类别中分别选择了既往没有乳腺癌或当前使用激素的受试者。获取危险因素信息、人体测量数据和血液样本，并测量雌二醇、黄体酮、性激素结合球蛋白、生长激素、胰岛素样生长因子-I及其主要结合蛋白和催乳素。乳房X线照片被数字化并使用计算机辅助方法进行测量。在调整其他危险因素后，我们发现绝经前女性的血清胰岛素样生长因子-I 水平和绝经后女性的血清催乳素水平均与百分比密度显着呈正相关。两组中总雌二醇和孕酮水平与百分比密度无关。在绝经后妇女中，游离雌二醇（负）和性激素结合球蛋白（正）与百分比密度显着相关。这些数据显示了乳腺有丝分裂原的血液水平与乳房X线照相密度之间的关联，并提出了乳腺癌相关风险的生物学基础。英国癌症杂志 (2002) 87, 876–882。 doi:10.1038/sj.bjc.6600537 www.bjcancer.com © 2002 英国癌症研究中心
Radiologically dense breast tissue (mammographic density) is strongly associated with risk of breast cancer, but the biological basis for this association is unknown. In this study we have examined the association of circulating levels of hormones and growth factors with mammographic density. A total of 382 subjects, 193 premenopausal and 189 postmenopausal, without previous breast cancer or current hormone use, were selected in each of five categories of breast density from mammography units. Risk factor information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured. Mammograms were digitised and measured using a computer-assisted method. After adjustment for other risk factors, we found in premenopausal women that serum insulin-like growth factor-I levels, and in postmenopausal women, serum levels of prolactin, were both significantly and positively associated with per cent density. Total oestradiol and progesterone levels were unrelated to per cent density in both groups. In postmenopausal women, free oestradiol (negatively), and sex hormone binding globulin (positively), were significantly related to per cent density. These data show an association between blood levels of breast mitogens and mammographic density, and suggest a biological basis for the associated risk of breast cancer. British Journal of Cancer (2002) 87, 876–882. doi:10.1038/sj.bjc.6600537 www.bjcancer.com © 2002 Cancer Research UK
登录
查看更多内容
影响因子：
--
作者：
Considine, RV
通讯作者：
Considine, RV
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
DOI：
10.1016/s0960-0760(99)00092-8
发表时间：
1999-07-01
影响因子：
4.1
作者：
Fortunati, N;Fissore, F;Frairia, R
通讯作者：
Frairia, R
影响因子：
3.5
作者：
Byng, JW;Boyd, NF;Yaffe, MJ
通讯作者：
Yaffe, MJ
DOI：
10.1001/archpedi.1987.04460050104041
发表时间：
1987-05-01
影响因子：
--
作者：
CARA, JF;ROSENFIELD, RL;FURLANETTO, RW
通讯作者：
FURLANETTO, RW