NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia.

NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia.
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DOI:
10.1038/s42003-021-02330-8
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发表时间:
2021-06-29
影响因子:
5.9
通讯作者:
Volk A
Volk A
中科院分区:
生物学2区
文献类型:
--
作者:
Volk A

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在最近一期的《科学进展》杂志上,Srivastava等人报道了UBR 7在NOTCH 1驱动的T-ALL中的一种新的核苷酸生物合成调节作用。在这里,我们将讨论他们的关键发现和使用癌症代谢来了解T-ALL的发展和进展的影响。
In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.
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