Caspofungin modulates inflammatory responses to Aspergillus fumigatus through stage-specific effects on fungal beta-glucan exposure.
Caspofungin modulates inflammatory responses to Aspergillus fumigatus through stage-specific effects on fungal beta-glucan exposure.
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卡泊芬净通过对真菌 β-葡聚糖暴露的阶段特异性影响来调节烟曲霉的炎症反应。
DOI：
10.1086/589304
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发表时间：
2008-07-15
期刊：
影响因子：
--
通讯作者：
Pamer EG
中科院分区：
文献类型：
--
作者：
Hohl TM;Feldmesser M;Perlin DS;Pamer EG
Echinocandins target fungal β-1,3 glucan synthesis and are used clinically to treat invasive aspergillosis. Although echinocandins do not completely inhibit in vitro growth of Aspergillus fumigatus, they do induce morphological changes in fungal hyphae. Because β-1,3 glucans activate host antifungal pathways via the Dectin-1 receptor, we investigated the effect of echinocandins on inflammatory responses to A. fumigatus. Caspofungin- or micafungin-treated conidia and germlings induced less secretion of tumor necrosis factor (TNF) and CXCL2 by macrophages than did their untreated counterparts. Diminished secretion of TNF and CXCL2 correlated with diminished β-glucan exposure on echinocandin-treated germ tubes. In contrast to treated conidia and germlings, echinocandin-treated hyphae stimulated increased release of TNF and CXCL2 by macrophages and demonstrated intense staining with a β-glucan-specific antibody, particularly at hyphal tips. Our experiments demonstrate that echinocandin-induced morphological changes in A. fumigatus hyphae are accompanied by increased β-glucan exposure, with consequent increases in Dectin-1-mediated inflammatory responses by macrophages.
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影响因子：
4.9
作者：
Abruzzo, GK;Gill, CJ;Rosen, H
通讯作者：
Rosen, H
DOI：
10.1016/s0732-8893(00)00236-4
发表时间：
2001-02-01
影响因子：
2.9
作者：
Chiller, T;Farrokhshad, K;Stevens, DA
通讯作者：
Stevens, DA
影响因子：
3.2
作者：
Fontaine, T;Hartland, RP;Latge, JP
通讯作者：
Latge, JP
影响因子：
4.9
作者：
Lewis, Russell E.;Chamilos, Georgios;Kontoyiannis, Dimitrios P.
通讯作者：
Kontoyiannis, Dimitrios P.
影响因子：
3.1
作者：
Ibrahim-Granet, O;Philippe, B;Latgé, JP
通讯作者：
Latgé, JP