Comparing selection on S. aureus between antimicrobial peptides and common antibiotics.
Comparing selection on S. aureus between antimicrobial peptides and common antibiotics.
复制标题
比较抗菌肽和常见抗生素之间对金黄色葡萄球菌的选择。
DOI：
10.1371/journal.pone.0076521
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Rolff J
中科院分区：
文献类型：
--
作者：
Dobson AJ;Purves J;Kamysz W;Rolff J
随着有效抗生素数量的减少，人们对开发抗微生物肽（AMP）作为药物产生了兴趣。然而，任何新药都面临着潜在的细菌耐药性演变。在这里，我们通过实验比较了由三种AMP（来自哺乳动物，两栖动物和昆虫），两种AMP的组合和两种抗生素选择的金黄色葡萄球菌的耐药性演变：强大的最后手段万古霉素和经典的链霉素。我们发现，对单一抗菌肽和链霉素的耐药性很容易发展，没有可检测的健身成本。然而，对来自我们的AMP组合的选择的响应导致灭绝，其方式在定性上与万古霉素相似。这与以下假设一致：在免疫应答期间同时释放多种AMP是限制AMP抗性病原体进化的因素。
With a diminishing number of effective antibiotics, there has been interest in developing antimicrobial peptides (AMPs) as drugs. However, any new drug faces potential bacterial resistance evolution. Here, we experimentally compare resistance evolution in Staphylococcus aureus selected by three AMPs (from mammals, amphibians and insects), a combination of two AMPs, and two antibiotics: the powerful last-resort vancomycin and the classic streptomycin. We find that resistance evolves readily against single AMPs and against streptomycin, with no detectable fitness cost. However the response to selection from our combination of AMPs led to extinction, in a fashion qualitatively similar to vancomycin. This is consistent with the hypothesis that simultaneous release of multiple AMPs during immune responses is a factor which constrains evolution of AMP resistant pathogens.
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